HLA-DRB1

major histocompatibility complex, class II, DR beta 1

Link to human ortholog


Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31160572 Human NO
31183403 IMR-90 Human YES

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
immunoglobulin production involved in immunoglobulin mediated immune response [GO:0002381],
inflammatory response to antigenic stimulus [GO:0002437],
humoral immune response mediated by circulating immunoglobulin [GO:0002455],
peptide antigen assembly with MHC class II protein complex [GO:0002503],
negative regulation of inflammatory response to antigenic stimulus [GO:0002862],
immune response [GO:0006955],
cytoskeleton organization [GO:0007010],
signal transduction [GO:0007165],
epidermis development [GO:0008544],
detection of bacterium [GO:0016045],
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886],
macrophage differentiation [GO:0030225],
regulation of interleukin-4 production [GO:0032673],
negative regulation of interferon-gamma production [GO:0032689],
positive regulation of kinase activity [GO:0033674],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
T-helper 1 type immune response [GO:0042088],
negative regulation of T cell proliferation [GO:0042130],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of monocyte differentiation [GO:0045657],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of viral entry into host cell [GO:0046598],
T cell receptor signaling pathway [GO:0050852],
protein tetramerization [GO:0051262],
interferon-gamma-mediated signaling pathway [GO:0060333],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
regulation of interleukin-10 secretion [GO:2001179],

Molecular Function:
structural constituent of cytoskeleton [GO:0005200],
protein binding [GO:0005515],
MHC class II protein complex binding [GO:0023026],
polysaccharide binding [GO:0030247],
MHC class II receptor activity [GO:0032395],
peptide antigen binding [GO:0042605],
CD4 receptor binding [GO:0042609],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular space [GO:0005615],
lysosomal membrane [GO:0005765],
intermediate filament [GO:0005882],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
ER to Golgi transport vesicle membrane [GO:0012507],
membrane [GO:0016020],
transport vesicle membrane [GO:0030658],
endocytic vesicle membrane [GO:0030666],
clathrin-coated endocytic vesicle membrane [GO:0030669],
late endosome membrane [GO:0031902],
trans-Golgi network membrane [GO:0032588],
MHC class II protein complex [GO:0042613],
extracellular exosome [GO:0070062],
integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556],