HIF1A

hypoxia inducible factor 1 subunit alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
22684333 BJ Human NO
31584878 A-10 Rat NO
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
16161047 HHUA, Ishikawa, HWCA Human NO
20706634 AGS, MKN28 Human NO
23764844 hTERT RPE-1, HCT 116 Human NO
23928864 Primary progenitor cells derived from endothelium Human NO
24984035 HDF Human NO
28634450 HUVEC Human, rat NO
29548335 Li Fraumeni Human YES
30706629 hpMSC Human NO

GO terms:

Biological Process:
angiogenesis [GO:0001525],
response to hypoxia [GO:0001666],
neural crest cell migration [GO:0001755],
epithelial to mesenchymal transition [GO:0001837],
embryonic placenta development [GO:0001892],
B-1 B cell homeostasis [GO:0001922],
positive regulation of endothelial cell proliferation [GO:0001938],
heart looping [GO:0001947],
positive regulation of neuroblast proliferation [GO:0002052],
connective tissue replacement involved in inflammatory response wound healing [GO:0002248],
outflow tract morphogenesis [GO:0003151],
cardiac ventricle morphogenesis [GO:0003208],
lactate metabolic process [GO:0006089],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription from RNA polymerase II promoter [GO:0006366],
cellular iron ion homeostasis [GO:0006879],
signal transduction [GO:0007165],
lactation [GO:0007595],
visual learning [GO:0008542],
response to iron ion [GO:0010039],
regulation of gene expression [GO:0010468],
vascular endothelial growth factor production [GO:0010573],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of epithelial cell migration [GO:0010634],
positive regulation of receptor biosynthetic process [GO:0010870],
response to muscle activity [GO:0014850],
positive regulation of macroautophagy [GO:0016239],
protein ubiquitination [GO:0016567],
protein deubiquitination [GO:0016579],
cytokine-mediated signaling pathway [GO:0019221],
axonal transport of mitochondrion [GO:0019896],
neural fold elevation formation [GO:0021502],
cerebral cortex development [GO:0021987],
negative regulation of bone mineralization [GO:0030502],
positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949],
negative regulation of TOR signaling [GO:0032007],
oxygen homeostasis [GO:0032364],
positive regulation of chemokine production [GO:0032722],
regulation of transforming growth factor beta2 production [GO:0032909],
collagen metabolic process [GO:0032963],
embryonic hemopoiesis [GO:0035162],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
hemoglobin biosynthetic process [GO:0042541],
glucose homeostasis [GO:0042593],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619],
post-translational protein modification [GO:0043687],
positive regulation of erythrocyte differentiation [GO:0045648],
positive regulation of angiogenesis [GO:0045766],
positive regulation of glycolytic process [GO:0045821],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of growth [GO:0045926],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
muscle cell cellular homeostasis [GO:0046716],
positive regulation of hormone biosynthetic process [GO:0046886],
digestive tract morphogenesis [GO:0048546],
positive regulation of nitric-oxide synthase activity [GO:0051000],
cartilage development [GO:0051216],
elastin metabolic process [GO:0051541],
intestinal epithelial cell maturation [GO:0060574],
epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030],
iris morphogenesis [GO:0061072],
retina vasculature development in camera-type eye [GO:0061298],
regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418],
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419],
positive regulation of chemokine-mediated signaling pathway [GO:0070101],
negative regulation of thymocyte apoptotic process [GO:0070244],
cellular response to interleukin-1 [GO:0071347],
cellular response to hypoxia [GO:0071456],
dopaminergic neuron differentiation [GO:0071542],
hypoxia-inducible factor-1alpha signaling pathway [GO:0097411],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377],
positive regulation of mitophagy [GO:1903599],
regulation of aerobic respiration [GO:1903715],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
negative regulation of mesenchymal cell apoptotic process [GO:2001054],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
blood vessel development [GO:0001568],
vasculature development [GO:0001944],
regulation of glycolytic process [GO:0006110],
positive regulation of cell proliferation [GO:0008284],
positive regulation of autophagy [GO:0010508],
cell differentiation [GO:0030154],
negative regulation of ossification [GO:0030279],
regulation of cell proliferation [GO:0042127],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of gluconeogenesis [GO:0045722],
negative regulation of vasoconstriction [GO:0045906],
blood vessel morphogenesis [GO:0048514],
camera-type eye morphogenesis [GO:0048593],
positive regulation of smooth muscle cell proliferation [GO:0048661],
regulation of catalytic activity [GO:0050790],
response to fungicide [GO:0060992],
regulation of thymocyte apoptotic process [GO:0070243],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
p53 binding [GO:0002039],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
ubiquitin protein ligase binding [GO:0031625],
histone acetyltransferase binding [GO:0035035],
nuclear hormone receptor binding [GO:0035257],
histone deacetylase binding [GO:0042826],
sequence-specific DNA binding [GO:0043565],
protein heterodimerization activity [GO:0046982],
Hsp90 protein binding [GO:0051879],
E-box binding [GO:0070888],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
DNA binding [GO:0003677],
macromolecular complex binding [GO:0044877],
protein dimerization activity [GO:0046983],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
nuclear body [GO:0016604],
nuclear speck [GO:0016607],
motile cilium [GO:0031514],
macromolecular complex [GO:0032991],
RNA polymerase II transcription factor complex [GO:0090575],
axon cytoplasm [GO:1904115],