HFE

homeostatic iron regulator

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
23169885 Primary epithelial cells derived from retina Mouse NO

GO terms:

Biological Process:
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474],
negative regulation of T cell antigen processing and presentation [GO:0002626],
negative regulation of T cell cytokine production [GO:0002725],
cellular iron ion homeostasis [GO:0006879],
acute-phase response [GO:0006953],
female pregnancy [GO:0007565],
response to iron ion [GO:0010039],
cellular response to iron ion starvation [GO:0010106],
positive regulation of gene expression [GO:0010628],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
antigen processing and presentation [GO:0019882],
BMP signaling pathway [GO:0030509],
positive regulation of protein binding [GO:0032092],
negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435],
transferrin transport [GO:0033572],
regulation of iron ion transport [GO:0034756],
hormone biosynthetic process [GO:0042446],
positive regulation of receptor-mediated endocytosis [GO:0048260],
iron ion homeostasis [GO:0055072],
multicellular organismal iron ion homeostasis [GO:0060586],
macromolecular complex assembly [GO:0065003],
cellular response to iron ion [GO:0071281],
positive regulation of peptide hormone secretion [GO:0090277],
liver regeneration [GO:0097421],
iron ion import across plasma membrane [GO:0098711],
negative regulation of receptor binding [GO:1900121],
positive regulation of receptor binding [GO:1900122],
negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:1904283],
positive regulation of ferrous iron binding [GO:1904434],
positive regulation of transferrin receptor binding [GO:1904437],
response to iron ion starvation [GO:1990641],
regulation of protein localization to cell surface [GO:2000008],
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059],
negative regulation of receptor activity [GO:2000272],
positive regulation of receptor activity [GO:2000273],
negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186],
ion transport [GO:0006811],

Molecular Function:
receptor binding [GO:0005102],
protein binding [GO:0005515],
beta-2-microglobulin binding [GO:0030881],
co-receptor binding [GO:0039706],
peptide antigen binding [GO:0042605],
transferrin receptor binding [GO:1990459],

Cellular Component:
extracellular space [GO:0005615],
nucleoplasm [GO:0005654],
early endosome [GO:0005769],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
cytoplasmic vesicle [GO:0031410],
MHC class I protein complex [GO:0042612],
apical part of cell [GO:0045177],
basal part of cell [GO:0045178],
perinuclear region of cytoplasm [GO:0048471],
recycling endosome [GO:0055037],
terminal web [GO:1990357],
HFE-transferrin receptor complex [GO:1990712],
membrane [GO:0016020],
integral component of membrane [GO:0016021],