HES1

hes family bHLH transcription factor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
33238152 Primaryfibroblastsderivedfromskin Human NO
31155234 heart heart Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28151468 Primary mesenchymal stem cells derived from bone marrow Human NO
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES
31915373 Hheart_LA_VS healthy nan Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
liver development [GO:0001889],
embryonic heart tube morphogenesis [GO:0003143],
outflow tract morphogenesis [GO:0003151],
regulation of secondary heart field cardioblast proliferation [GO:0003266],
ventricular septum development [GO:0003281],
cell adhesion [GO:0007155],
Notch signaling pathway [GO:0007219],
smoothened signaling pathway [GO:0007224],
nervous system development [GO:0007399],
positive regulation of cell proliferation [GO:0008284],
anterior/posterior pattern specification [GO:0009952],
cell migration [GO:0016477],
telencephalon development [GO:0021537],
midbrain-hindbrain boundary morphogenesis [GO:0021555],
oculomotor nerve development [GO:0021557],
trochlear nerve development [GO:0021558],
hindbrain morphogenesis [GO:0021575],
forebrain radial glial cell differentiation [GO:0021861],
adenohypophysis development [GO:0021984],
cell differentiation [GO:0030154],
lung development [GO:0030324],
positive regulation of BMP signaling pathway [GO:0030513],
midbrain development [GO:0030901],
pancreas development [GO:0031016],
somatic stem cell population maintenance [GO:0035019],
ascending aorta morphogenesis [GO:0035910],
positive regulation of T cell proliferation [GO:0042102],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
positive regulation of DNA binding [GO:0043388],
regulation of fat cell differentiation [GO:0045598],
negative regulation of auditory receptor cell differentiation [GO:0045608],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of Notch signaling pathway [GO:0045747],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of mitotic cell cycle, embryonic [GO:0045977],
lateral inhibition [GO:0046331],
regulation of JAK-STAT cascade [GO:0046425],
positive regulation of JAK-STAT cascade [GO:0046427],
cell maturation [GO:0048469],
thymus development [GO:0048538],
cell morphogenesis involved in neuron differentiation [GO:0048667],
positive regulation of astrocyte differentiation [GO:0048711],
negative regulation of oligodendrocyte differentiation [GO:0048715],
artery morphogenesis [GO:0048844],
regulation of epithelial cell proliferation [GO:0050678],
regulation of neurogenesis [GO:0050767],
inner ear receptor stereocilium organization [GO:0060122],
regulation of timing of neuron differentiation [GO:0060164],
negative regulation of glial cell proliferation [GO:0060253],
ventricular septum morphogenesis [GO:0060412],
ureteric bud morphogenesis [GO:0060675],
labyrinthine layer blood vessel development [GO:0060716],
common bile duct development [GO:0061009],
negative regulation of stomach neuroendocrine cell differentiation [GO:0061106],
cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309],
pharyngeal arch artery morphogenesis [GO:0061626],
macromolecular complex assembly [GO:0065003],
glomerulus vasculature development [GO:0072012],
comma-shaped body morphogenesis [GO:0072049],
S-shaped body morphogenesis [GO:0072050],
renal interstitial fibroblast development [GO:0072141],
metanephric nephron tubule morphogenesis [GO:0072282],
cochlea development [GO:0090102],
establishment of epithelial cell polarity [GO:0090162],
vascular smooth muscle cell development [GO:0097084],
neuronal stem cell population maintenance [GO:0097150],
negative regulation of pancreatic A cell differentiation [GO:2000227],
negative regulation of stem cell differentiation [GO:2000737],
negative regulation of pro-B cell differentiation [GO:2000974],
negative regulation of forebrain neuron differentiation [GO:2000978],
in utero embryonic development [GO:0001701],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
pattern specification process [GO:0007389],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of neuron projection development [GO:0010977],
neural tube development [GO:0021915],
pituitary gland development [GO:0021983],
endocrine pancreas development [GO:0031018],
hair cell differentiation [GO:0035315],
aorta morphogenesis [GO:0035909],
regulation of protein complex assembly [GO:0043254],
cell fate commitment [GO:0045165],
negative regulation of cell differentiation [GO:0045596],
positive regulation of glial cell differentiation [GO:0045687],
regulation of timing of cell differentiation [GO:0048505],
negative regulation of neurogenesis [GO:0050768],
negative regulation of calcium ion import [GO:0090281],
cellular response to nerve growth factor stimulus [GO:1990090],
negative regulation of inner ear receptor cell differentiation [GO:2000981],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
protein homodimerization activity [GO:0042803],
histone deacetylase binding [GO:0042826],
HLH domain binding [GO:0043398],
sequence-specific DNA binding [GO:0043565],
chaperone binding [GO:0051087],
E-box binding [GO:0070888],
N-box binding [GO:0071820],
bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding [GO:0001217],
chromatin binding [GO:0003682],
JUN kinase binding [GO:0008432],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
protein dimerization activity [GO:0046983],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
macromolecular complex [GO:0032991],
chromatin [GO:0000785],
intracellular [GO:0005622],
nuclear matrix [GO:0016363],