heart development protein with EGF like domains 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
vasculogenesis [GO:0001570],
in utero embryonic development [GO:0001701],
endothelial cell morphogenesis [GO:0001886],
lymph vessel development [GO:0001945],
lymph circulation [GO:0003017],
cardiac atrium morphogenesis [GO:0003209],
ventricular trabecula myocardium morphogenesis [GO:0003222],
ventricular septum development [GO:0003281],
cell-cell junction assembly [GO:0007043],
heart development [GO:0007507],
post-embryonic development [GO:0009791],
lung development [GO:0030324],
negative regulation of Rho protein signal transduction [GO:0035024],
multicellular organism growth [GO:0035264],
venous blood vessel morphogenesis [GO:0048845],
regulation of body fluid levels [GO:0050878],
cardiac muscle tissue growth [GO:0055017],
pericardium development [GO:0060039],
positive regulation of fibroblast growth factor production [GO:0090271],
protein localization to cell junction [GO:1902414],
negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299],
endothelial cell development [GO:0001885],
vasculature development [GO:0001944],
multicellular organism development [GO:0007275],
cell-cell junction organization [GO:0045216],

Molecular Function:
calcium ion binding [GO:0005509],
protein binding [GO:0005515],

Cellular Component:
extracellular region [GO:0005576],
cell-cell junction [GO:0005911],
external side of plasma membrane [GO:0009897],
integral component of membrane [GO:0016021],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
membrane [GO:0016020],
cell junction [GO:0030054],