HDAC9

histone deacetylase 9

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
30666570 Primary fibroblasts derived from skin Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
response to amphetamine [GO:0001975],
inflammatory response [GO:0006954],
heart development [GO:0007507],
histone deacetylation [GO:0016575],
neuron differentiation [GO:0030182],
B cell differentiation [GO:0030183],
cellular response to insulin stimulus [GO:0032869],
peptidyl-lysine deacetylation [GO:0034983],
B cell activation [GO:0042113],
cholesterol homeostasis [GO:0042632],
negative regulation of transcription, DNA-templated [GO:0045892],
regulation of skeletal muscle fiber development [GO:0048742],
negative regulation of cytokine secretion [GO:0050710],
negative regulation of lipoprotein lipase activity [GO:0051005],
regulation of striated muscle cell differentiation [GO:0051153],
histone H3 deacetylation [GO:0070932],
histone H4 deacetylation [GO:0070933],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
histone H4-K16 deacetylation [GO:1990678],
DNA repair [GO:0006281],
chromatin organization [GO:0006325],
nervous system development [GO:0007399],
determination of adult lifespan [GO:0008340],
negative regulation of striated muscle tissue development [GO:0045843],

Molecular Function:
transcription corepressor activity [GO:0003714],
histone deacetylase activity [GO:0004407],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
NAD-dependent histone deacetylase activity (H3-K14 specific) [GO:0032041],
protein deacetylase activity [GO:0033558],
histone deacetylase activity (H4-K16 specific) [GO:0034739],
histone deacetylase binding [GO:0042826],
metal ion binding [GO:0046872],
repressing transcription factor binding [GO:0070491],
hydrolase activity [GO:0016787],

Cellular Component:
histone deacetylase complex [GO:0000118],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
histone methyltransferase complex [GO:0035097],