HDAC6

histone deacetylase 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29427610 AGS Human NO
30666570 Primary fibroblasts derived from skin Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
protein deacetylation [GO:0006476],
misfolded or incompletely synthesized protein catabolic process [GO:0006515],
intracellular protein transport [GO:0006886],
autophagy [GO:0006914],
negative regulation of microtubule depolymerization [GO:0007026],
regulation of autophagy [GO:0010506],
positive regulation of epithelial cell migration [GO:0010634],
negative regulation of hydrogen peroxide metabolic process [GO:0010727],
positive regulation of receptor biosynthetic process [GO:0010870],
regulation of macroautophagy [GO:0016241],
histone deacetylation [GO:0016575],
negative regulation of protein complex assembly [GO:0031333],
regulation of protein stability [GO:0031647],
protein destabilization [GO:0031648],
lysosome localization [GO:0032418],
macromolecular complex disassembly [GO:0032984],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
peptidyl-lysine deacetylation [GO:0034983],
cellular response to topologically incorrect protein [GO:0035967],
regulation of gene expression, epigenetic [GO:0040029],
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162],
negative regulation of protein complex disassembly [GO:0043242],
regulation of fat cell differentiation [GO:0045598],
negative regulation of proteolysis [GO:0045861],
negative regulation of transcription, DNA-templated [GO:0045892],
collateral sprouting [GO:0048668],
negative regulation of oxidoreductase activity [GO:0051354],
mitochondrion localization [GO:0051646],
response to misfolded protein [GO:0051788],
cilium assembly [GO:0060271],
regulation of microtubule-based movement [GO:0060632],
regulation of androgen receptor signaling pathway [GO:0060765],
dendritic spine morphogenesis [GO:0060997],
parkin-mediated mitophagy in response to mitochondrial depolarization [GO:0061734],
regulation of establishment of protein localization [GO:0070201],
cellular response to hydrogen peroxide [GO:0070301],
aggresome assembly [GO:0070842],
polyubiquitinated misfolded protein transport [GO:0070845],
Hsp90 deacetylation [GO:0070846],
response to growth factor [GO:0070848],
histone H3 deacetylation [GO:0070932],
cellular response to misfolded protein [GO:0071218],
tubulin deacetylation [GO:0090042],
positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300],
regulation of mitophagy [GO:1903146],
chromatin organization [GO:0006325],
ubiquitin-dependent protein catabolic process [GO:0006511],
skeletal muscle tissue development [GO:0007519],
myotube differentiation [GO:0014902],
mitophagy in response to mitochondrial depolarization [GO:0098779],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
actin binding [GO:0003779],
histone deacetylase activity [GO:0004407],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
microtubule binding [GO:0008017],
zinc ion binding [GO:0008270],
enzyme binding [GO:0019899],
polyubiquitin binding [GO:0031593],
ubiquitin protein ligase binding [GO:0031625],
NAD-dependent histone deacetylase activity (H3-K14 specific) [GO:0032041],
protein deacetylase activity [GO:0033558],
histone deacetylase binding [GO:0042826],
tubulin deacetylase activity [GO:0042903],
alpha-tubulin binding [GO:0043014],
ubiquitin binding [GO:0043130],
acetylspermidine deacetylase activity [GO:0047611],
tau protein binding [GO:0048156],
beta-tubulin binding [GO:0048487],
misfolded protein binding [GO:0051787],
Hsp90 protein binding [GO:0051879],
dynein complex binding [GO:0070840],
hydrolase activity [GO:0016787],
deacetylase activity [GO:0019213],
metal ion binding [GO:0046872],

Cellular Component:
histone deacetylase complex [GO:0000118],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
multivesicular body [GO:0005771],
cytosol [GO:0005829],
microtubule [GO:0005874],
microtubule associated complex [GO:0005875],
cytoplasmic microtubule [GO:0005881],
caveola [GO:0005901],
inclusion body [GO:0016234],
aggresome [GO:0016235],
dynein complex [GO:0030286],
axon [GO:0030424],
dendrite [GO:0030425],
cell leading edge [GO:0031252],
perikaryon [GO:0043204],
perinuclear region of cytoplasm [GO:0048471],
centrosome [GO:0005813],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
macromolecular complex [GO:0032991],
cell projection [GO:0042995],
neuron projection [GO:0043005],
cell body [GO:0044297],