histone deacetylase 10

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30666570 Primary fibroblasts derived from skin Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
DNA repair [GO:0006281],
chromatin organization [GO:0006325],
regulation of transcription, DNA-templated [GO:0006355],
protein deacetylation [GO:0006476],
oligodendrocyte development [GO:0014003],
macroautophagy [GO:0016236],
histone deacetylation [GO:0016575],
positive regulation of mismatch repair [GO:0032425],
peptidyl-lysine deacetylation [GO:0034983],
reciprocal DNA recombination [GO:0035825],
negative regulation of transcription, DNA-templated [GO:0045892],
DNA recombination [GO:0006310],
autophagy [GO:0006914],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
histone deacetylase activity [GO:0004407],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
deacetylase activity [GO:0019213],
enzyme binding [GO:0019899],
protein deacetylase activity [GO:0033558],
histone deacetylase binding [GO:0042826],
acetylputrescine deacetylase activity [GO:0047609],
acetylspermidine deacetylase activity [GO:0047611],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
histone deacetylase complex [GO:0000118],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],