HBEGF

heparin binding EGF like growth factor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
19682489 Primary mammary epithelial cells derived from breast Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
30285098 HT-1080 Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
signal transduction [GO:0007165],
epidermal growth factor receptor signaling pathway [GO:0007173],
muscle organ development [GO:0007517],
regulation of heart contraction [GO:0008016],
positive regulation of cell proliferation [GO:0008284],
positive regulation of cell growth [GO:0030307],
positive regulation of cell migration [GO:0030335],
wound healing, spreading of epidermal cells [GO:0035313],
ERBB2 signaling pathway [GO:0038128],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
positive regulation of epidermal growth factor-activated receptor activity [GO:0045741],
positive regulation of smooth muscle cell proliferation [GO:0048661],
negative regulation of elastin biosynthetic process [GO:0051545],
positive regulation of keratinocyte migration [GO:0051549],
positive regulation of protein kinase B signaling [GO:0051897],
cell chemotaxis [GO:0060326],
membrane organization [GO:0061024],
positive regulation of wound healing [GO:0090303],
regulation of cell motility [GO:2000145],
angiogenesis [GO:0001525],
blastocyst growth [GO:0001832],
cell migration [GO:0016477],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],

Molecular Function:
epidermal growth factor receptor binding [GO:0005154],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
clathrin-coated vesicle membrane [GO:0030665],
endocytic vesicle membrane [GO:0030666],
clathrin-coated endocytic vesicle membrane [GO:0030669],
membrane [GO:0016020],
integral component of membrane [GO:0016021],