HAP1

huntingtin associated protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein targeting [GO:0006605],
exocytosis [GO:0006887],
autophagy [GO:0006914],
chemical synaptic transmission [GO:0007268],
brain development [GO:0007420],
anterograde axonal transport [GO:0008089],
retrograde axonal transport [GO:0008090],
protein localization [GO:0008104],
regulation of exocytosis [GO:0017157],
cerebellum development [GO:0021549],
hypothalamus cell differentiation [GO:0021979],
neurogenesis [GO:0022008],
cell projection organization [GO:0030030],
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587],
positive regulation of synaptic transmission, GABAergic [GO:0032230],
positive regulation of neurotrophin production [GO:0032901],
positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742],
vesicle transport along microtubule [GO:0047496],
neurotrophin TRK receptor signaling pathway [GO:0048011],
mitochondrion distribution [GO:0048311],
positive regulation of neurogenesis [GO:0050769],
anterograde axonal transport of mitochondrion [GO:0098957],
negative regulation of beta-amyloid formation [GO:1902430],
regulation of organelle transport along microtubule [GO:1902513],
positive regulation of non-motile cilium assembly [GO:1902857],
positive regulation of neuron projection development [GO:0010976],
protein transport [GO:0015031],
neuron projection development [GO:0031175],
positive regulation of inclusion body assembly [GO:0090261],

Molecular Function:
receptor binding [GO:0005102],
protein binding [GO:0005515],
myosin binding [GO:0017022],
ion channel binding [GO:0044325],
brain-derived neurotrophic factor binding [GO:0048403],
protein domain specific binding [GO:0019904],
identical protein binding [GO:0042802],

Cellular Component:
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
lysosome [GO:0005764],
early endosome [GO:0005769],
autophagosome [GO:0005776],
endoplasmic reticulum [GO:0005783],
centrosome [GO:0005813],
centriole [GO:0005814],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
synaptic vesicle [GO:0008021],
actin cytoskeleton [GO:0015629],
inclusion body [GO:0016234],
dendrite [GO:0030425],
growth cone [GO:0030426],
cytoplasmic vesicle [GO:0031410],
dendritic spine [GO:0043197],
axon cytoplasm [GO:1904115],
nucleus [GO:0005634],
endosome [GO:0005768],
cell junction [GO:0030054],
cell projection [GO:0042995],
neuron projection [GO:0043005],
axon terminus [GO:0043679],
synapse [GO:0045202],
perinuclear region of cytoplasm [GO:0048471],
GABA-ergic synapse [GO:0098982],
presynaptic cytosol [GO:0099523],
postsynaptic cytosol [GO:0099524],