H2AX

H2A.X variant histone

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30508396 Primary cells derived from muscle Human NO
30666570 Primary fibroblasts derived from skin Human NO
30693443 Cochlea Mouse NO
30854802 Primary progenitor cells derived from heart Human NO
30920150 Primary vascular progenitor cells derived from artery Human YES
30967634 HUVEC Human YES
31002926 Primary cells derived from intervertebral disc Human NO
31103748 A549 Human NO
31186408 OV-90,OV-1369,OV-4453,OV-1946 Human
31250942 BT-549, MDA‐MB‐231 Human NO
31431479 B16-F1 Human NO
31447100 Primary fibroblasts derived from skin Human NO
31469660 Primary neurons derived from brain, MEF Rat, mouse NO
31469894 Cornea Mouse NO
31725940 Bone Mouse NO
31811121 IMR-90 Human NO
32005663 HCT 116, MCF7 Human NO
32012719 Primary epithelial ovarian cancer cells Human NO
32046944 HT23 Mouse NO
32158519 HUVEC Human NO
32023548 U-2 OS, Saos-2 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
32042076 Primary fibroblasts derived from skin Human NO

GO terms:

Biological Process:
DNA damage checkpoint [GO:0000077],
double-strand break repair via homologous recombination [GO:0000724],
double-strand break repair [GO:0006302],
double-strand break repair via nonhomologous end joining [GO:0006303],
chromatin organization [GO:0006325],
nucleosome assembly [GO:0006334],
chromatin silencing [GO:0006342],
cellular response to DNA damage stimulus [GO:0006974],
spermatogenesis [GO:0007283],
response to ionizing radiation [GO:0010212],
viral process [GO:0016032],
cerebral cortex development [GO:0021987],
positive regulation of DNA repair [GO:0045739],
meiotic cell cycle [GO:0051321],
cellular response to gamma radiation [GO:0071480],
cellular senescence [GO:0090398],
DNA repair [GO:0006281],
DNA recombination [GO:0006310],
cell cycle [GO:0007049],

Molecular Function:
DNA binding [GO:0003677],
damaged DNA binding [GO:0003684],
protein binding [GO:0005515],
enzyme binding [GO:0019899],
histone binding [GO:0042393],
protein heterodimerization activity [GO:0046982],

Cellular Component:
chromosome, telomeric region [GO:0000781],
nucleosome [GO:0000786],
nuclear chromatin [GO:0000790],
condensed nuclear chromosome [GO:0000794],
male germ cell nucleus [GO:0001673],
XY body [GO:0001741],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
replication fork [GO:0005657],
centrosome [GO:0005813],
nuclear speck [GO:0016607],
site of double-strand break [GO:0035861],
extracellular exosome [GO:0070062],
chromatin [GO:0000785],
chromosome [GO:0005694],