ankyrin repeat domain 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31935369 PC-9 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO
31915373 Hheart_LV_VS healthy Cardiomyocyte Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
positive regulation of neuron projection development [GO:0010976],
regulation of lipid metabolic process [GO:0019216],
cellular response to drug [GO:0035690],
skeletal muscle cell differentiation [GO:0035914],
response to muscle stretch [GO:0035994],
positive regulation of apoptotic process [GO:0043065],
positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517],
sarcomere organization [GO:0045214],
positive regulation of protein secretion [GO:0050714],
cardiac muscle tissue morphogenesis [GO:0055008],
protein kinase C signaling [GO:0070528],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to mechanical stimulus [GO:0071260],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to organic cyclic compound [GO:0071407],
cellular response to hypoxia [GO:0071456],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of nucleic acid-templated transcription [GO:1903508],
negative regulation of DNA biosynthetic process [GO:2000279],

Molecular Function:
RNA polymerase II transcription factor binding [GO:0001085],
p53 binding [GO:0002039],
DNA binding [GO:0003677],
transcription coactivator activity [GO:0003713],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
titin binding [GO:0031432],
histone deacetylase binding [GO:0042826],
RNA polymerase II sequence-specific DNA binding transcription factor binding [GO:0061629],
R-SMAD binding [GO:0070412],
transcription factor binding [GO:0008134],

Cellular Component:
fibrillar center [GO:0001650],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
I band [GO:0031674],
myofibril [GO:0030016],
macromolecular complex [GO:0032991],