GSR

glutathione-disulfide reductase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31934025 MRC-6 Human NO
31983656 IPSC-MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
16189290 Kidney Rat NO
31983656 MSC Human YES

GO terms:

Biological Process:
glutathione metabolic process [GO:0006749],
nucleobase-containing small molecule interconversion [GO:0015949],
electron transport chain [GO:0022900],
cellular response to oxidative stress [GO:0034599],
cell redox homeostasis [GO:0045454],
cellular oxidant detoxification [GO:0098869],
spermatogenesis [GO:0007283],
oxidation-reduction process [GO:0055114],

Molecular Function:
glutathione-disulfide reductase activity [GO:0004362],
electron carrier activity [GO:0009055],
flavin adenine dinucleotide binding [GO:0050660],
NADP binding [GO:0050661],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [GO:0016668],
identical protein binding [GO:0042802],
glutathione binding [GO:0043295],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
cytosol [GO:0005829],
external side of plasma membrane [GO:0009897],
extracellular exosome [GO:0070062],
cytoplasm [GO:0005737],