GSN

gelsolin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30987592 MCF7 Breast Human YES
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
phagocytosis, engulfment [GO:0006911],
central nervous system development [GO:0007417],
aging [GO:0007568],
actin polymerization or depolymerization [GO:0008154],
positive regulation of gene expression [GO:0010628],
oligodendrocyte development [GO:0014003],
striated muscle atrophy [GO:0014891],
extracellular matrix disassembly [GO:0022617],
cell projection assembly [GO:0030031],
actin filament polymerization [GO:0030041],
regulation of cell adhesion [GO:0030155],
protein destabilization [GO:0031648],
tissue regeneration [GO:0042246],
sequestering of actin monomers [GO:0042989],
neutrophil degranulation [GO:0043312],
cellular protein metabolic process [GO:0044267],
actin nucleation [GO:0045010],
response to ethanol [GO:0045471],
negative regulation of viral entry into host cell [GO:0046597],
phosphatidylinositol-mediated signaling [GO:0048015],
actin filament severing [GO:0051014],
barbed-end actin filament capping [GO:0051016],
positive regulation of actin nucleation [GO:0051127],
response to folic acid [GO:0051593],
actin filament capping [GO:0051693],
cilium assembly [GO:0060271],
cellular response to cadmium ion [GO:0071276],
cellular response to interferon-gamma [GO:0071346],
regulation of podosome assembly [GO:0071801],
actin filament reorganization [GO:0090527],
renal protein absorption [GO:0097017],
hepatocyte apoptotic process [GO:0097284],
positive regulation of keratinocyte apoptotic process [GO:1902174],
regulation of establishment of T cell polarity [GO:1903903],
regulation of plasma membrane raft polarization [GO:1903906],
regulation of receptor clustering [GO:1903909],
positive regulation of protein processing in phagocytic vesicle [GO:1903923],
amyloid fibril formation [GO:1990000],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269],
apoptotic process [GO:0006915],
vesicle-mediated transport [GO:0016192],
cell projection organization [GO:0030030],

Molecular Function:
actin binding [GO:0003779],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
myosin II binding [GO:0045159],
actin filament binding [GO:0051015],
metal ion binding [GO:0046872],

Cellular Component:
ruffle [GO:0001726],
podosome [GO:0002102],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
sarcoplasm [GO:0016528],
lamellipodium [GO:0030027],
actin cap [GO:0030478],
cortical actin cytoskeleton [GO:0030864],
macromolecular complex [GO:0032991],
secretory granule lumen [GO:0034774],
myelin sheath [GO:0043209],
phagocytic vesicle [GO:0045335],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],
ficolin-1-rich granule lumen [GO:1904813],
cytoskeleton [GO:0005856],