GSK3B

glycogen synthase kinase 3 beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
18367674 MEF Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
20649541 HeLa Human NO
24917460 Mv 1 Lu Neovison vison NO
26618897 Primary chondrocytes derived from cartilage Cartilage Human NO
31727161 Brain Human NO
32109515 Brain Mouse NO
32148417 HDF Human NO

GO terms:

Biological Process:
epithelial to mesenchymal transition [GO:0001837],
positive regulation of cell-matrix adhesion [GO:0001954],
glycogen metabolic process [GO:0005977],
protein phosphorylation [GO:0006468],
ER overload response [GO:0006983],
signal transduction [GO:0007165],
dopamine receptor signaling pathway [GO:0007212],
circadian rhythm [GO:0007623],
insulin receptor signaling pathway [GO:0008286],
positive regulation of autophagy [GO:0010508],
positive regulation of gene expression [GO:0010628],
positive regulation of mitochondrion organization [GO:0010822],
regulation of neuron projection development [GO:0010975],
Wnt signaling pathway [GO:0016055],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
hippocampus development [GO:0021766],
establishment of cell polarity [GO:0030010],
maintenance of cell polarity [GO:0030011],
regulation of axon extension [GO:0030516],
neuron projection development [GO:0031175],
negative regulation of protein complex assembly [GO:0031333],
positive regulation of protein complex assembly [GO:0031334],
negative regulation of protein binding [GO:0032091],
positive regulation of protein binding [GO:0032092],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
negative regulation of phosphoprotein phosphatase activity [GO:0032515],
regulation of microtubule-based process [GO:0032886],
intracellular signal transduction [GO:0035556],
cellular response to interleukin-3 [GO:0036016],
regulation of circadian rhythm [GO:0042752],
negative regulation of apoptotic process [GO:0043066],
positive regulation of GTPase activity [GO:0043547],
negative regulation of glycogen biosynthetic process [GO:0045719],
positive regulation of protein catabolic process [GO:0045732],
protein autophosphorylation [GO:0046777],
positive regulation of protein export from nucleus [GO:0046827],
regulation of dendrite morphogenesis [GO:0048814],
regulation of axonogenesis [GO:0050770],
excitatory postsynaptic potential [GO:0060079],
regulation of microtubule cytoskeleton organization [GO:0070507],
negative regulation of calcineurin-NFAT signaling cascade [GO:0070885],
superior temporal gyrus development [GO:0071109],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
extrinsic apoptotic signaling pathway [GO:0097191],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
regulation of cellular response to heat [GO:1900034],
negative regulation of protein localization to nucleus [GO:1900181],
regulation of long-term synaptic potentiation [GO:1900271],
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030],
negative regulation of neuron death [GO:1901215],
positive regulation of neuron death [GO:1901216],
negative regulation of protein acetylation [GO:1901984],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
negative regulation of dopaminergic neuron differentiation [GO:1904339],
cellular response to beta-amyloid [GO:1904646],
positive regulation of protein localization to centrosome [GO:1904781],
beta-catenin destruction complex assembly [GO:1904885],
beta-catenin destruction complex disassembly [GO:1904886],
negative regulation of type B pancreatic cell development [GO:2000077],
regulation of synaptic vesicle exocytosis [GO:2000300],
negative regulation of glycogen (starch) synthase activity [GO:2000466],
re-entry into mitotic cell cycle [GO:0000320],
regulation of cell growth [GO:0001558],
carbohydrate metabolic process [GO:0005975],
regulation of gene expression by genetic imprinting [GO:0006349],
protein export from nucleus [GO:0006611],
cytoskeleton organization [GO:0007010],
establishment or maintenance of cell polarity [GO:0007163],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
axonogenesis [GO:0007409],
myoblast fusion [GO:0007520],
animal organ morphogenesis [GO:0009887],
negative regulation of signal transduction [GO:0009968],
response to zinc ion [GO:0010043],
negative regulation of cardiac muscle hypertrophy [GO:0010614],
positive regulation of peptidyl-threonine phosphorylation [GO:0010800],
positive regulation of mitochondrial membrane potential [GO:0010918],
negative regulation of neuron projection development [GO:0010977],
negative regulation of neuron maturation [GO:0014043],
myotube differentiation [GO:0014902],
phosphorylation [GO:0016310],
cell migration [GO:0016477],
cell differentiation [GO:0030154],
negative regulation of TOR signaling [GO:0032007],
positive regulation of osteoblast proliferation [GO:0033690],
negative regulation of smooth muscle cell apoptotic process [GO:0034392],
protein localization to microtubule [GO:0035372],
cellular response to hepatocyte growth factor stimulus [GO:0035729],
hepatic stellate cell activation [GO:0035733],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of MAP kinase activity [GO:0043407],
positive regulation of neuron apoptotic process [GO:0043525],
hypermethylation of CpG island [GO:0044027],
fat cell differentiation [GO:0045444],
regulation of osteoblast differentiation [GO:0045667],
positive regulation of osteoclast differentiation [GO:0045672],
positive regulation of axon extension [GO:0045773],
negative regulation of synaptic growth at neuromuscular junction [GO:0045886],
positive regulation of synaptic growth at neuromuscular junction [GO:0045887],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
bone remodeling [GO:0046849],
regulation of neuronal synaptic plasticity [GO:0048168],
rhythmic process [GO:0048511],
positive regulation of smooth muscle cell proliferation [GO:0048661],
negative regulation of dendrite morphogenesis [GO:0050774],
negative regulation of nitric-oxide synthase activity [GO:0051001],
canonical Wnt signaling pathway [GO:0060070],
cell growth involved in cardiac muscle cell development [GO:0061049],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
cellular response to mechanical stimulus [GO:0071260],
positive regulation of osteoclast proliferation [GO:0090290],
hepatocyte apoptotic process [GO:0097284],
negative regulation of protein localization to centrosome [GO:1904780],
negative regulation of dendrite development [GO:2000171],
positive regulation of excitatory postsynaptic potential [GO:2000463],
positive regulation of DNA biosynthetic process [GO:2000573],
positive regulation of cardiac muscle cell differentiation [GO:2000727],
positive regulation of stem cell differentiation [GO:2000738],
negative regulation of neuron migration [GO:2001223],

Molecular Function:
RNA polymerase II transcription factor binding [GO:0001085],
protease binding [GO:0002020],
p53 binding [GO:0002039],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
beta-catenin binding [GO:0008013],
kinase activity [GO:0016301],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
protein kinase A catalytic subunit binding [GO:0034236],
dynactin binding [GO:0034452],
tau protein binding [GO:0048156],
tau-protein kinase activity [GO:0050321],
NF-kappaB binding [GO:0051059],
nucleotide binding [GO:0000166],
integrin binding [GO:0005178],
transcription factor binding [GO:0008134],
transferase activity [GO:0016740],
ionotropic glutamate receptor binding [GO:0035255],
dynein complex binding [GO:0070840],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
centrosome [GO:0005813],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
axon [GO:0030424],
dendrite [GO:0030425],
beta-catenin destruction complex [GO:0030877],
postsynapse [GO:0098794],
glutamatergic synapse [GO:0098978],
Wnt signalosome [GO:1990909],
microtubule [GO:0005874],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
growth cone [GO:0030426],
macromolecular complex [GO:0032991],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
dendritic shaft [GO:0043198],
membrane-bounded organelle [GO:0043227],
cell body [GO:0044297],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
ribonucleoprotein complex [GO:1990904],