glutamate ionotropic receptor AMPA type subunit 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
signal transduction [GO:0007165],
chemical synaptic transmission [GO:0007268],
ion transmembrane transport [GO:0034220],
ionotropic glutamate receptor signaling pathway [GO:0035235],
synaptic transmission, glutamatergic [GO:0035249],
regulation of postsynaptic membrane potential [GO:0060078],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
regulation of receptor recycling [GO:0001919],
ion transport [GO:0006811],
receptor internalization [GO:0031623],
establishment of protein localization [GO:0045184],
positive regulation of synaptic transmission [GO:0050806],
protein tetramerization [GO:0051262],
regulation of synaptic transmission, glutamatergic [GO:0051966],

Molecular Function:
beta-amyloid binding [GO:0001540],
ionotropic glutamate receptor activity [GO:0004970],
AMPA glutamate receptor activity [GO:0004971],
protein binding [GO:0005515],
ligand-gated ion channel activity [GO:0015276],
signaling receptor activity [GO:0038023],
SNARE binding [GO:0000149],
ion channel activity [GO:0005216],
extracellular-glutamate-gated ion channel activity [GO:0005234],
cytoskeletal protein binding [GO:0008092],
kainate selective glutamate receptor activity [GO:0015277],
immunoglobulin binding [GO:0019865],
protein kinase binding [GO:0019901],
PDZ domain binding [GO:0030165],
glutamate receptor binding [GO:0035254],
identical protein binding [GO:0042802],
ATPase binding [GO:0051117],
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315],

Cellular Component:
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
external side of plasma membrane [GO:0009897],
postsynaptic density [GO:0014069],
dendrite [GO:0030425],
endocytic vesicle membrane [GO:0030666],
asymmetric synapse [GO:0032279],
AMPA glutamate receptor complex [GO:0032281],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
excitatory synapse [GO:0060076],
postsynapse [GO:0098794],
postsynaptic endocytic zone [GO:0098843],
endoplasmic reticulum [GO:0005783],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
growth cone [GO:0030426],
synaptic vesicle membrane [GO:0030672],
dendrite cytoplasm [GO:0032839],
macromolecular complex [GO:0032991],
somatodendritic compartment [GO:0036477],
presynaptic membrane [GO:0042734],
neuron projection [GO:0043005],
terminal bouton [GO:0043195],
dendritic shaft [GO:0043198],
perikaryon [GO:0043204],
synapse [GO:0045202],
postsynaptic membrane [GO:0045211],
synaptic membrane [GO:0097060],
postsynaptic density membrane [GO:0098839],
glutamatergic synapse [GO:0098978],
integral component of postsynaptic membrane [GO:0099055],
integral component of presynaptic membrane [GO:0099056],
integral component of postsynaptic density membrane [GO:0099061],
perisynaptic space [GO:0099544],