ANK2

ankyrin 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
30988157 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
17940615 Heart Mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
regulation of heart rate [GO:0002027],
atrial septum development [GO:0003283],
cellular calcium ion homeostasis [GO:0006874],
ER to Golgi vesicle-mediated transport [GO:0006888],
endocytosis [GO:0006897],
cytoskeleton organization [GO:0007010],
positive regulation of gene expression [GO:0010628],
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881],
regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882],
protein transport [GO:0015031],
paranodal junction assembly [GO:0030913],
regulation of protein stability [GO:0031647],
T-tubule organization [GO:0033292],
protein localization to organelle [GO:0033365],
protein localization to cell surface [GO:0034394],
cellular protein localization [GO:0034613],
protein localization to M-band [GO:0036309],
protein localization to T-tubule [GO:0036371],
positive regulation of potassium ion transport [GO:0043268],
protein stabilization [GO:0050821],
regulation of release of sequestered calcium ion into cytosol [GO:0051279],
response to methylmercury [GO:0051597],
regulation of calcium ion transport [GO:0051924],
positive regulation of calcium ion transport [GO:0051928],
regulation of cardiac muscle contraction [GO:0055117],
regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307],
sarcoplasmic reticulum calcium ion transport [GO:0070296],
protein localization to endoplasmic reticulum [GO:0070972],
protein localization to plasma membrane [GO:0072659],
regulation of cardiac muscle cell contraction [GO:0086004],
ventricular cardiac muscle cell action potential [GO:0086005],
atrial cardiac muscle cell action potential [GO:0086014],
SA node cell action potential [GO:0086015],
membrane depolarization during SA node cell action potential [GO:0086046],
atrial cardiac muscle cell to AV node cell communication [GO:0086066],
SA node cell to atrial cardiac muscle cell communication [GO:0086070],
regulation of heart rate by cardiac conduction [GO:0086091],
regulation of SA node cell action potential [GO:0098907],
regulation of atrial cardiac muscle cell action potential [GO:0098910],
positive regulation of potassium ion transmembrane transporter activity [GO:1901018],
regulation of calcium ion transmembrane transporter activity [GO:1901019],
positive regulation of calcium ion transmembrane transporter activity [GO:1901021],
positive regulation of cation channel activity [GO:2001259],
signal transduction [GO:0007165],
protein localization [GO:0008104],
regulation of apoptotic process [GO:0042981],
cardiac muscle contraction [GO:0060048],
regulation of cardiac muscle cell membrane potential [GO:0086036],
regulation of AV node cell action potential [GO:0098904],
regulation of cation channel activity [GO:2001257],

Molecular Function:
structural constituent of cytoskeleton [GO:0005200],
protein binding [GO:0005515],
cytoskeletal adaptor activity [GO:0008093],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
spectrin binding [GO:0030507],
protein binding, bridging [GO:0030674],
ion channel binding [GO:0044325],
ATPase binding [GO:0051117],
potassium channel regulator activity [GO:0015459],

Cellular Component:
mitochondrion [GO:0005739],
lysosome [GO:0005764],
early endosome [GO:0005769],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
intercalated disc [GO:0014704],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
Z disc [GO:0030018],
T-tubule [GO:0030315],
M band [GO:0031430],
A band [GO:0031672],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
costamere [GO:0043034],
membrane raft [GO:0045121],
postsynaptic membrane [GO:0045211],
recycling endosome [GO:0055037],
cytoplasm [GO:0005737],
endosome [GO:0005768],
integral component of plasma membrane [GO:0005887],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
cell junction [GO:0030054],
synapse [GO:0045202],
perinuclear region of cytoplasm [GO:0048471],