GPC3

glypican 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31155234 heart heart Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21847365 Huh7, HepG3 Human NO
31612616 Huh-7, Hep3B Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
retinoid metabolic process [GO:0001523],
branching involved in ureteric bud morphogenesis [GO:0001658],
glycosaminoglycan biosynthetic process [GO:0006024],
glycosaminoglycan catabolic process [GO:0006027],
response to bacterium [GO:0009617],
anatomical structure morphogenesis [GO:0009653],
anterior/posterior axis specification [GO:0009948],
body morphogenesis [GO:0010171],
negative regulation of peptidase activity [GO:0010466],
cell migration [GO:0016477],
bone mineralization [GO:0030282],
osteoclast differentiation [GO:0030316],
lung development [GO:0030324],
positive regulation of BMP signaling pathway [GO:0030513],
embryonic hindlimb morphogenesis [GO:0035116],
cell migration involved in gastrulation [GO:0042074],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
positive regulation of protein catabolic process [GO:0045732],
positive regulation of endocytosis [GO:0045807],
negative regulation of smoothened signaling pathway [GO:0045879],
positive regulation of smoothened signaling pathway [GO:0045880],
negative regulation of growth [GO:0045926],
positive regulation of glucose import [GO:0046326],
negative regulation of epithelial cell proliferation [GO:0050680],
regulation of canonical Wnt signaling pathway [GO:0060828],
coronary vasculature development [GO:0060976],
cell proliferation involved in kidney development [GO:0072111],
mesenchymal cell proliferation involved in ureteric bud development [GO:0072138],
mesonephric duct morphogenesis [GO:0072180],
cell proliferation involved in metanephros development [GO:0072203],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
regulation of protein localization to membrane [GO:1905475],
regulation of non-canonical Wnt signaling pathway [GO:2000050],
positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096],
kidney development [GO:0001822],
negative regulation of cell proliferation [GO:0008285],
animal organ morphogenesis [GO:0009887],
regulation of signal transduction [GO:0009966],
regulation of growth [GO:0040008],

Molecular Function:
protein binding [GO:0005515],
peptidyl-dipeptidase inhibitor activity [GO:0060422],
peptidase inhibitor activity [GO:0030414],

Cellular Component:
extracellular region [GO:0005576],
endoplasmic reticulum lumen [GO:0005788],
Golgi lumen [GO:0005796],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
intrinsic component of plasma membrane [GO:0031226],
lysosomal lumen [GO:0043202],
anchored component of plasma membrane [GO:0046658],
lysosome [GO:0005764],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
anchored component of membrane [GO:0031225],