GOT2

glutamic-oxaloacetic transaminase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29352139 293T, PaTu 8988t, Panc-1, PL45, PaTu 892 Human NO

GO terms:

Biological Process:
gluconeogenesis [GO:0006094],
2-oxoglutarate metabolic process [GO:0006103],
oxaloacetate metabolic process [GO:0006107],
aspartate metabolic process [GO:0006531],
aspartate biosynthetic process [GO:0006532],
aspartate catabolic process [GO:0006533],
glutamate metabolic process [GO:0006536],
female pregnancy [GO:0007565],
lactation [GO:0007595],
cellular amino acid biosynthetic process [GO:0008652],
response to muscle activity [GO:0014850],
fatty acid transport [GO:0015908],
4-hydroxyproline catabolic process [GO:0019470],
glutamate catabolic process to aspartate [GO:0019550],
glutamate catabolic process to 2-oxoglutarate [GO:0019551],
response to insulin [GO:0032868],
response to morphine [GO:0043278],
response to ethanol [GO:0045471],
glyoxylate metabolic process [GO:0046487],
L-kynurenine metabolic process [GO:0097052],
cellular amino acid metabolic process [GO:0006520],
lipid transport [GO:0006869],
biosynthetic process [GO:0009058],
dicarboxylic acid metabolic process [GO:0043648],

Molecular Function:
RNA binding [GO:0003723],
L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069],
phospholipid binding [GO:0005543],
kynurenine-oxoglutarate transaminase activity [GO:0016212],
amino acid binding [GO:0016597],
enzyme binding [GO:0019899],
pyridoxal phosphate binding [GO:0030170],
identical protein binding [GO:0042802],
catalytic activity [GO:0003824],
transaminase activity [GO:0008483],
transferase activity [GO:0016740],
carboxylic acid binding [GO:0031406],
L-phenylalanine:2-oxoglutarate aminotransferase activity [GO:0080130],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial inner membrane [GO:0005743],
mitochondrial matrix [GO:0005759],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
T-tubule [GO:0030315],
macromolecular complex [GO:0032991],
perikaryon [GO:0043204],
extracellular exosome [GO:0070062],
membrane [GO:0016020],
sarcolemma [GO:0042383],
myelin sheath [GO:0043209],