ANGPTL4

angiopoietin like 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA591 Skin, Lung Human YES
30988157 IMR-90 Human YES
31148378 MRC-5 Human YES
31534052 Kidney Mouse YES
31860636 2BS, 293T  Human YES
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
lipid metabolic process [GO:0006629],
regulation of lipid metabolic process [GO:0019216],
negative regulation of apoptotic process [GO:0043066],
protein unfolding [GO:0043335],
positive regulation of angiogenesis [GO:0045766],
negative regulation of lipoprotein lipase activity [GO:0051005],
triglyceride homeostasis [GO:0070328],
negative regulation of endothelial cell apoptotic process [GO:2000352],
cellular response to starvation [GO:0009267],
positive regulation of lipid metabolic process [GO:0045834],

Molecular Function:
enzyme inhibitor activity [GO:0004857],
receptor binding [GO:0005102],
protein binding [GO:0005515],
identical protein binding [GO:0042802],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
blood microparticle [GO:0072562],