angiopoietin 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
response to hypoxia [GO:0001666],
signal transduction [GO:0007165],
germ cell development [GO:0007281],
response to radiation [GO:0009314],
response to mechanical stimulus [GO:0009612],
response to glucose [GO:0009749],
gene expression [GO:0010467],
negative regulation of cell-substrate adhesion [GO:0010812],
response to organic cyclic compound [GO:0014070],
response to activity [GO:0014823],
negative regulation of angiogenesis [GO:0016525],
animal organ regeneration [GO:0031100],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
positive regulation of angiogenesis [GO:0045766],
Tie signaling pathway [GO:0048014],
leukocyte migration [GO:0050900],
negative regulation of positive chemotaxis [GO:0050928],
maternal process involved in female pregnancy [GO:0060135],
cellular response to growth factor stimulus [GO:0071363],
glomerulus vasculature development [GO:0072012],
blood vessel remodeling [GO:0001974],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
multicellular organism development [GO:0007275],
endoderm development [GO:0007492],
hemopoiesis [GO:0030097],
cell differentiation [GO:0030154],
regulation of angiogenesis [GO:0045765],
blood vessel morphogenesis [GO:0048514],

Molecular Function:
receptor binding [GO:0005102],
protein binding [GO:0005515],
receptor tyrosine kinase binding [GO:0030971],
metal ion binding [GO:0046872],
vascular endothelial growth factor receptor binding [GO:0005172],
receptor antagonist activity [GO:0048019],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
plasma membrane [GO:0005886],
cell projection [GO:0042995],