ABCC8

ATP binding cassette subfamily C member 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31155496 Primary β cells derived from pancreas Mouse YES

GO terms:

Biological Process:
potassium ion transport [GO:0006813],
regulation of insulin secretion [GO:0050796],
transmembrane transport [GO:0055085],
potassium ion transmembrane transport [GO:0071805],
inorganic cation transmembrane transport [GO:0098662],
cellular glucose homeostasis [GO:0001678],
memory [GO:0007613],
visual learning [GO:0008542],
response to pH [GO:0009268],
response to zinc ion [GO:0010043],
negative regulation of low-density lipoprotein particle clearance [GO:0010989],
negative regulation of angiogenesis [GO:0016525],
positive regulation of tumor necrosis factor production [GO:0032760],
positive regulation of potassium ion transport [GO:0043268],
negative regulation of insulin secretion [GO:0046676],
negative regulation of neurogenesis [GO:0050768],
negative regulation of glial cell proliferation [GO:0060253],
negative regulation of wound healing [GO:0061045],
cellular response to organic substance [GO:0071310],
positive regulation of uterine smooth muscle relaxation [GO:1900721],
positive regulation of voltage-gated potassium channel activity [GO:1903818],
positive regulation of occluding junction disassembly [GO:1905075],

Molecular Function:
potassium channel activity [GO:0005267],
ATP binding [GO:0005524],
sulfonylurea receptor activity [GO:0008281],
ATP-activated inward rectifier potassium channel activity [GO:0015272],
ATPase activity [GO:0016887],
cation-transporting ATPase activity [GO:0019829],
ATPase activity, coupled to transmembrane movement of substances [GO:0042626],
ion channel binding [GO:0044325],

Cellular Component:
plasma membrane [GO:0005886],
ATP-sensitive potassium channel complex [GO:0008282],
membrane [GO:0016020],
potassium ion-transporting ATPase complex [GO:0031004],
mitochondrion [GO:0005739],
synaptic vesicle membrane [GO:0030672],
sarcolemma [GO:0042383],