glutamate-ammonia ligase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31915373 Hheart_LV_VS healthy nan Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
neurotransmitter uptake [GO:0001504],
angiogenesis [GO:0001525],
glutamate catabolic process [GO:0006538],
glutamine biosynthetic process [GO:0006542],
cell proliferation [GO:0008283],
cellular amino acid biosynthetic process [GO:0008652],
cellular response to starvation [GO:0009267],
response to glucose [GO:0009749],
regulation of endothelial cell migration [GO:0010594],
protein palmitoylation [GO:0018345],
ammonia assimilation cycle [GO:0019676],
positive regulation of insulin secretion [GO:0032024],
ribosome biogenesis [GO:0042254],
positive regulation of epithelial cell proliferation [GO:0050679],
positive regulation of synaptic transmission, glutamatergic [GO:0051968],
regulation of sprouting angiogenesis [GO:1903670],
regulation of protein localization to nucleolus [GO:1904749],
glutamate metabolic process [GO:0006536],
nitrogen compound metabolic process [GO:0006807],

Molecular Function:
magnesium ion binding [GO:0000287],
glutamate-ammonia ligase activity [GO:0004356],
protein binding [GO:0005515],
ATP binding [GO:0005524],
glutamate binding [GO:0016595],
protein-cysteine S-palmitoyltransferase activity [GO:0019706],
manganese ion binding [GO:0030145],
identical protein binding [GO:0042802],
dynein light chain binding [GO:0045503],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
transferase activity [GO:0016740],
ligase activity [GO:0016874],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
rough endoplasmic reticulum [GO:0005791],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
macromolecular complex [GO:0032991],
perikaryon [GO:0043204],
myelin sheath [GO:0043209],
axon terminus [GO:0043679],
extracellular exosome [GO:0070062],
glial cell projection [GO:0097386],
endoplasmic reticulum [GO:0005783],
membrane [GO:0016020],
cell projection [GO:0042995],
neuron projection [GO:0043005],
intracellular membrane-bounded organelle [GO:0043231],
cell body [GO:0044297],