angiopoietin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31219154 MCF10A Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
20453494 Primary glomerular endothelial cells Mouse NO
29548335 Li Fraumeni Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
angiogenesis [GO:0001525],
in utero embryonic development [GO:0001701],
negative regulation of protein phosphorylation [GO:0001933],
positive regulation of protein phosphorylation [GO:0001934],
regulation of endothelial cell proliferation [GO:0001936],
sprouting angiogenesis [GO:0002040],
positive regulation of receptor internalization [GO:0002092],
negative regulation of cytokine production involved in immune response [GO:0002719],
negative regulation of cell adhesion [GO:0007162],
activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of gene expression [GO:0010628],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
regulation of skeletal muscle satellite cell proliferation [GO:0014842],
hemopoiesis [GO:0030097],
cell differentiation [GO:0030154],
heparin biosynthetic process [GO:0030210],
positive regulation of protein ubiquitination [GO:0031398],
regulation of tumor necrosis factor production [GO:0032680],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
protein localization to cell surface [GO:0034394],
negative regulation of protein import into nucleus [GO:0042308],
negative regulation of apoptotic process [GO:0043066],
negative regulation of vascular permeability [GO:0043116],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
regulation of protein binding [GO:0043393],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of cell adhesion [GO:0045785],
Tie signaling pathway [GO:0048014],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
leukocyte migration [GO:0050900],
positive chemotaxis [GO:0050918],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
glomerulus vasculature development [GO:0072012],
negative regulation of endothelial cell apoptotic process [GO:2000352],
regulation of macrophage migration inhibitory factor signaling pathway [GO:2000446],
ovarian follicle development [GO:0001541],
patterning of blood vessels [GO:0001569],
vasculogenesis [GO:0001570],
endocardium morphogenesis [GO:0003160],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
multicellular organism development [GO:0007275],
endoderm development [GO:0007492],
positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949],
cell-substrate adhesion [GO:0031589],
cardiac muscle tissue morphogenesis [GO:0055008],
vasculogenesis involved in coronary vascular morphogenesis [GO:0060979],

Molecular Function:
receptor binding [GO:0005102],
receptor tyrosine kinase binding [GO:0030971],
vascular endothelial growth factor receptor binding [GO:0005172],
protein binding [GO:0005515],
identical protein binding [GO:0042802],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
microvillus [GO:0005902],
membrane raft [GO:0045121],
extracellular exosome [GO:0070062],