GLI3

GLI family zinc finger 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
metanephros development [GO:0001656],
branching involved in ureteric bud morphogenesis [GO:0001658],
in utero embryonic development [GO:0001701],
positive regulation of neuroblast proliferation [GO:0002052],
smoothened signaling pathway [GO:0007224],
axon guidance [GO:0007411],
hindgut morphogenesis [GO:0007442],
heart development [GO:0007507],
negative regulation of cell proliferation [GO:0008285],
anterior/posterior pattern specification [GO:0009952],
proximal/distal pattern formation [GO:0009954],
protein processing [GO:0016485],
optic nerve morphogenesis [GO:0021631],
hippocampus development [GO:0021766],
smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775],
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776],
forebrain dorsal/ventral pattern formation [GO:0021798],
layer formation in cerebral cortex [GO:0021819],
forebrain radial glial cell differentiation [GO:0021861],
lateral ganglionic eminence cell proliferation [GO:0022018],
melanocyte differentiation [GO:0030318],
lung development [GO:0030324],
prostate gland development [GO:0030850],
positive regulation of chondrocyte differentiation [GO:0032332],
T cell differentiation in thymus [GO:0033077],
limb morphogenesis [GO:0035108],
wound healing [GO:0042060],
positive regulation of protein import into nucleus [GO:0042307],
odontogenesis of dentin-containing tooth [GO:0042475],
embryonic digit morphogenesis [GO:0042733],
negative regulation of apoptotic process [GO:0043066],
nose morphogenesis [GO:0043585],
tongue development [GO:0043586],
response to estrogen [GO:0043627],
negative thymic T cell selection [GO:0045060],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of osteoblast differentiation [GO:0045669],
negative regulation of smoothened signaling pathway [GO:0045879],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of alpha-beta T cell differentiation [GO:0046638],
negative regulation of alpha-beta T cell differentiation [GO:0046639],
embryonic digestive tract morphogenesis [GO:0048557],
embryonic digestive tract development [GO:0048566],
developmental growth [GO:0048589],
camera-type eye morphogenesis [GO:0048593],
embryonic neurocranium morphogenesis [GO:0048702],
oligodendrocyte differentiation [GO:0048709],
palate development [GO:0060021],
frontal suture morphogenesis [GO:0060364],
lambdoid suture morphogenesis [GO:0060366],
sagittal suture morphogenesis [GO:0060367],
mammary gland specification [GO:0060594],
smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831],
artery development [GO:0060840],
anterior semicircular canal development [GO:0060873],
lateral semicircular canal development [GO:0060875],
cell differentiation involved in kidney development [GO:0061005],
thymocyte apoptotic process [GO:0070242],
vocalization behavior [GO:0071625],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
liver regeneration [GO:0097421],
regulation of bone development [GO:1903010],
kidney development [GO:0001822],
regulation of transcription, DNA-templated [GO:0006355],
pattern specification process [GO:0007389],
central nervous system development [GO:0007417],
brain development [GO:0007420],
dorsal/ventral pattern formation [GO:0009953],
regulation of gene expression [GO:0010468],
spinal cord dorsal/ventral patterning [GO:0021513],
spinal cord motor neuron differentiation [GO:0021522],
telencephalon development [GO:0021537],
pallium development [GO:0021543],
subpallium development [GO:0021544],
cerebral cortex radial glia guided migration [GO:0021801],
neural tube development [GO:0021915],
embryonic limb morphogenesis [GO:0030326],
mammary gland development [GO:0030879],
forebrain development [GO:0030900],
tube development [GO:0035295],
regulation of cell proliferation [GO:0042127],
regulation of apoptotic process [GO:0042981],
camera-type eye development [GO:0043010],
regulation of cell differentiation [GO:0045595],
negative regulation of cell differentiation [GO:0045596],
embryonic organ development [GO:0048568],
embryonic morphogenesis [GO:0048598],
anatomical structure formation involved in morphogenesis [GO:0048646],
neuron fate commitment [GO:0048663],
embryonic skeletal system morphogenesis [GO:0048704],
branching morphogenesis of an epithelial tube [GO:0048754],
inner ear development [GO:0048839],
anatomical structure development [GO:0048856],
limb development [GO:0060173],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
histone acetyltransferase binding [GO:0035035],
mediator complex binding [GO:0036033],
histone deacetylase binding [GO:0042826],
metal ion binding [GO:0046872],
nucleic acid binding [GO:0003676],
DNA binding [GO:0003677],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cilium [GO:0005929],
axoneme [GO:0005930],
nuclear speck [GO:0016607],
transcriptional repressor complex [GO:0017053],
ciliary tip [GO:0097542],
ciliary base [GO:0097546],
cell projection [GO:0042995],