GLI2

GLI family zinc finger 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
skeletal system development [GO:0001501],
in utero embryonic development [GO:0001701],
kidney development [GO:0001822],
chondrocyte differentiation [GO:0002062],
osteoblast development [GO:0002076],
smoothened signaling pathway [GO:0007224],
pattern specification process [GO:0007389],
axon guidance [GO:0007411],
ventral midline development [GO:0007418],
hindgut morphogenesis [GO:0007442],
heart development [GO:0007507],
anterior/posterior pattern specification [GO:0009952],
proximal/distal pattern formation [GO:0009954],
floor plate formation [GO:0021508],
spinal cord dorsal/ventral patterning [GO:0021513],
ventral spinal cord development [GO:0021517],
cerebellar cortex morphogenesis [GO:0021696],
smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775],
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776],
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938],
spinal cord ventral commissure morphogenesis [GO:0021965],
pituitary gland development [GO:0021983],
lung development [GO:0030324],
mammary gland development [GO:0030879],
hindbrain development [GO:0030902],
hair follicle morphogenesis [GO:0031069],
negative regulation of chondrocyte differentiation [GO:0032331],
positive regulation of T cell differentiation in thymus [GO:0033089],
tube development [GO:0035295],
odontogenesis of dentin-containing tooth [GO:0042475],
embryonic digit morphogenesis [GO:0042733],
negative regulation of apoptotic process [GO:0043066],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of DNA replication [GO:0045740],
negative regulation of smoothened signaling pathway [GO:0045879],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
embryonic digestive tract development [GO:0048566],
developmental growth [GO:0048589],
neuron development [GO:0048666],
branching morphogenesis of an epithelial tube [GO:0048754],
notochord regression [GO:0060032],
prostatic bud formation [GO:0060513],
mammary gland duct morphogenesis [GO:0060603],
smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831],
cellular response to organic cyclic compound [GO:0071407],
cochlea morphogenesis [GO:0090103],
osteoblast differentiation [GO:0001649],
morphogenesis of an epithelium [GO:0002009],
multicellular organism development [GO:0007275],
positive regulation of cell proliferation [GO:0008284],
epidermal cell differentiation [GO:0009913],
dorsal/ventral pattern formation [GO:0009953],
spinal cord motor neuron differentiation [GO:0021522],
dorsal/ventral neural tube patterning [GO:0021904],
neural tube development [GO:0021915],
cell differentiation [GO:0030154],
anatomical structure formation involved in morphogenesis [GO:0048646],
anatomical structure development [GO:0048856],
head development [GO:0060322],
cellular response to virus [GO:0098586],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
sequence-specific DNA binding [GO:0043565],
promoter-specific chromatin binding [GO:1990841],
transcription regulatory region sequence-specific DNA binding [GO:0000976],
nucleic acid binding [GO:0003676],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytosol [GO:0005829],
cilium [GO:0005929],
axoneme [GO:0005930],
membrane [GO:0016020],
nuclear speck [GO:0016607],
motile cilium [GO:0031514],
ciliary tip [GO:0097542],
ciliary base [GO:0097546],
cytoplasm [GO:0005737],
cell projection [GO:0042995],