anaphase promoting complex subunit 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA615 Skin, Lung Human YES

GO terms:

Biological Process:
ubiquitin-dependent protein catabolic process [GO:0006511],
cell cycle [GO:0007049],
anaphase-promoting complex-dependent catabolic process [GO:0031145],
positive regulation of mitotic metaphase/anaphase transition [GO:0045842],
cell division [GO:0051301],
protein K11-linked ubiquitination [GO:0070979],
regulation of mitotic cell cycle phase transition [GO:1901990],
regulation of mitotic metaphase/anaphase transition [GO:0030071],

Molecular Function:
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
protein phosphatase binding [GO:0019903],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
anaphase-promoting complex [GO:0005680],
cytosol [GO:0005829],
nuclear periphery [GO:0034399],