GCLC

glutamate-cysteine ligase catalytic subunit

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31934025 MRC-10 Human NO
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
cysteine metabolic process [GO:0006534],
glutamate metabolic process [GO:0006536],
glutathione biosynthetic process [GO:0006750],
response to oxidative stress [GO:0006979],
aging [GO:0007568],
response to nutrient [GO:0007584],
response to heat [GO:0009408],
response to xenobiotic stimulus [GO:0009410],
response to hormone [GO:0009725],
response to activity [GO:0014823],
L-ascorbic acid metabolic process [GO:0019852],
negative regulation of protein ubiquitination [GO:0031397],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
cellular response to insulin stimulus [GO:0032869],
cellular response to hepatocyte growth factor stimulus [GO:0035729],
negative regulation of apoptotic process [GO:0043066],
negative regulation of neuron apoptotic process [GO:0043524],
cellular response to fibroblast growth factor stimulus [GO:0044344],
response to human chorionic gonadotropin [GO:0044752],
cell redox homeostasis [GO:0045454],
negative regulation of transcription, DNA-templated [GO:0045892],
response to arsenic-containing substance [GO:0046685],
response to cadmium ion [GO:0046686],
response to nitrosative stress [GO:0051409],
regulation of mitochondrial depolarization [GO:0051900],
response to interleukin-1 [GO:0070555],
cellular response to mechanical stimulus [GO:0071260],
cellular response to glucose stimulus [GO:0071333],
cellular response to follicle-stimulating hormone stimulus [GO:0071372],
cellular response to thyroxine stimulus [GO:0097069],
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029],
negative regulation of hepatic stellate cell activation [GO:2000490],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
glutathione metabolic process [GO:0006749],

Molecular Function:
magnesium ion binding [GO:0000287],
glutamate-cysteine ligase activity [GO:0004357],
protein binding [GO:0005515],
ATP binding [GO:0005524],
glutamate binding [GO:0016595],
ADP binding [GO:0043531],
macromolecular complex binding [GO:0044877],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
ligase activity [GO:0016874],

Cellular Component:
mitochondrion [GO:0005739],
cytosol [GO:0005829],
glutamate-cysteine ligase complex [GO:0017109],