GBP2

guanylate binding protein 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
immune response [GO:0006955],
protein localization to nucleus [GO:0034504],
defense response to protozoan [GO:0042832],
defense response to Gram-positive bacterium [GO:0050830],
interferon-gamma-mediated signaling pathway [GO:0060333],
type I interferon signaling pathway [GO:0060337],
cellular response to interferon-gamma [GO:0071346],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
response to bacterium [GO:0009617],
cellular response to interferon-beta [GO:0035458],
adhesion of symbiont to host [GO:0044406],
cellular response to lipopolysaccharide [GO:0071222],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
hydrolase activity [GO:0016787],

Cellular Component:
Golgi membrane [GO:0000139],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
actin cytoskeleton [GO:0015629],
symbiont-containing vacuole membrane [GO:0020005],
cytoplasmic vesicle [GO:0031410],
perinuclear region of cytoplasm [GO:0048471],
membrane [GO:0016020],