glucosylceramidase beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28098348 Primary mesenchymal stem cells derived from bone marrow Human NO

GO terms:

Biological Process:
glucosylceramide catabolic process [GO:0006680],
glycosphingolipid metabolic process [GO:0006687],
autophagy [GO:0006914],
mitochondrion organization [GO:0007005],
lysosome organization [GO:0007040],
cholesterol metabolic process [GO:0008203],
cellular response to starvation [GO:0009267],
response to pH [GO:0009268],
regulation of macroautophagy [GO:0016241],
termination of signal transduction [GO:0023021],
lipid glycosylation [GO:0030259],
neuron projection development [GO:0031175],
negative regulation of protein complex assembly [GO:0031333],
regulation of TOR signaling [GO:0032006],
regulation of cellular protein metabolic process [GO:0032268],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
negative regulation of interleukin-6 production [GO:0032715],
regulation of water loss via skin [GO:0033561],
response to testosterone [GO:0033574],
positive regulation of protein dephosphorylation [GO:0035307],
cell death in response to oxidative stress [GO:0036473],
positive regulation of protein complex disassembly [GO:0043243],
negative regulation of MAP kinase activity [GO:0043407],
skin morphogenesis [GO:0043589],
response to estrogen [GO:0043627],
sphingosine biosynthetic process [GO:0046512],
ceramide biosynthetic process [GO:0046513],
negative regulation of inflammatory response [GO:0050728],
positive regulation of protein metabolic process [GO:0051247],
cellular response to tumor necrosis factor [GO:0071356],
response to dexamethasone [GO:0071548],
response to thyroid hormone [GO:0097066],
negative regulation of neuron death [GO:1901215],
beta-glucoside catabolic process [GO:1901805],
positive regulation of proteolysis involved in cellular protein catabolic process [GO:1903052],
positive regulation of protein lipidation [GO:1903061],
positive regulation of neuronal action potential [GO:1904457],
positive regulation of mitophagy in response to mitochondrial depolarization [GO:1904925],
autophagosome organization [GO:1905037],
regulation of lysosomal protein catabolic process [GO:1905165],
lipid metabolic process [GO:0006629],
sphingolipid metabolic process [GO:0006665],
glucosylceramide metabolic process [GO:0006678],
central nervous system development [GO:0007417],
metabolic process [GO:0008152],
steroid metabolic process [GO:0008202],
determination of adult lifespan [GO:0008340],
microglia differentiation [GO:0014004],
antigen processing and presentation [GO:0019882],
lipid storage [GO:0019915],
cerebellar Purkinje cell layer formation [GO:0021694],
pyramidal neuron differentiation [GO:0021859],
negative regulation of cellular protein metabolic process [GO:0032269],
T cell differentiation in thymus [GO:0033077],
T-helper 2 cell cytokine production [GO:0035745],
negative regulation of neuron apoptotic process [GO:0043524],
cell maturation [GO:0048469],
brain morphogenesis [GO:0048854],
homeostasis of number of cells [GO:0048872],
neurological system process [GO:0050877],
neuromuscular process [GO:0050905],
regulation of protein metabolic process [GO:0051246],
neuron apoptotic process [GO:0051402],
microglial cell proliferation [GO:0061518],
motor behavior [GO:0061744],
hematopoietic stem cell proliferation [GO:0071425],
lymphocyte migration [GO:0072676],

Molecular Function:
glucosylceramidase activity [GO:0004348],
receptor binding [GO:0005102],
scavenger receptor binding [GO:0005124],
protein binding [GO:0005515],
hydrolase activity [GO:0016787],
glucosyltransferase activity [GO:0046527],
steryl-beta-glucosidase activity [GO:0050295],
beta-glucosidase activity [GO:0008422],
transferase activity [GO:0016740],
transferase activity, transferring glycosyl groups [GO:0016757],
hydrolase activity, acting on glycosyl bonds [GO:0016798],

Cellular Component:
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
extrinsic component of membrane [GO:0019898],
lysosomal lumen [GO:0043202],
extracellular exosome [GO:0070062],
extracellular space [GO:0005615],
membrane [GO:0016020],