GATA4

GATA binding protein 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28401730 Primary osteoprogenitors derived from bone marrow Bone marrow Human, mouse, rat NO
29760459 Primary mesenchymal stem cells derived form blood Human NO
30371213 Primary myocytes derived from heart, primary fibroblasts derived from heart Heart Human, mouse, rat NO
30995348 Hep 3B, SMMC-7721, HepG2 Human NO
31762159 Primary neurons derived from brain Rat NO

GO terms:

Biological Process:
heart looping [GO:0001947],
aortic valve morphogenesis [GO:0003180],
atrioventricular valve formation [GO:0003190],
endocardial cushion development [GO:0003197],
cardiac ventricle morphogenesis [GO:0003208],
cardiac right ventricle morphogenesis [GO:0003215],
ventricular septum development [GO:0003281],
atrial septum primum morphogenesis [GO:0003289],
atrial septum secundum morphogenesis [GO:0003290],
regulation of transcription, DNA-templated [GO:0006355],
cell-cell signaling [GO:0007267],
endoderm development [GO:0007492],
blood coagulation [GO:0007596],
male gonad development [GO:0008584],
response to mechanical stimulus [GO:0009612],
negative regulation of autophagy [GO:0010507],
positive regulation of vascular endothelial growth factor production [GO:0010575],
negative regulation of cardiac muscle cell apoptotic process [GO:0010667],
positive regulation of BMP signaling pathway [GO:0030513],
response to vitamin A [GO:0033189],
embryonic heart tube anterior/posterior pattern specification [GO:0035054],
response to drug [GO:0042493],
cell fate commitment [GO:0045165],
positive regulation of angiogenesis [GO:0045766],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
embryonic foregut morphogenesis [GO:0048617],
positive regulation of cardioblast differentiation [GO:0051891],
regulation of protein kinase B signaling [GO:0051896],
transdifferentiation [GO:0060290],
atrial septum morphogenesis [GO:0060413],
intestinal epithelial cell differentiation [GO:0060575],
cardiac muscle tissue regeneration [GO:0061026],
cell growth involved in cardiac muscle cell development [GO:0061049],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to glucose stimulus [GO:0071333],
regulation of cardiac muscle cell contraction [GO:0086004],
negative regulation of oxidative stress-induced cell death [GO:1903202],
negative regulation of apoptotic signaling pathway [GO:2001234],
in utero embryonic development [GO:0001701],
gastrulation with mouth forming second [GO:0001702],
endoderm formation [GO:0001706],
positive regulation of protein phosphorylation [GO:0001934],
heart morphogenesis [GO:0003007],
outflow tract morphogenesis [GO:0003151],
atrioventricular valve morphogenesis [GO:0003181],
mitral valve formation [GO:0003192],
tricuspid valve formation [GO:0003195],
ventricular cardiac muscle tissue development [GO:0003229],
cardiac septum development [GO:0003279],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
spermatogenesis [GO:0007283],
heart development [GO:0007507],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
cardiac muscle hypertrophy in response to stress [GO:0014898],
signal transduction involved in regulation of gene expression [GO:0023019],
response to retinoic acid [GO:0032526],
embryonic heart tube development [GO:0035050],
tube morphogenesis [GO:0035239],
skeletal muscle cell differentiation [GO:0035914],
atrioventricular canal development [GO:0036302],
negative regulation of apoptotic process [GO:0043066],
response to estrogen [GO:0043627],
positive regulation of cell cycle [GO:0045787],
embryonic digestive tract morphogenesis [GO:0048557],
embryonic morphogenesis [GO:0048598],
cardiac muscle tissue development [GO:0048738],
cardiac muscle cell differentiation [GO:0055007],
Sertoli cell differentiation [GO:0060008],
regulation of cardiac muscle cell proliferation [GO:0060043],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
SMAD protein signal transduction [GO:0060395],
lung morphogenesis [GO:0060425],
lung lobe formation [GO:0060464],
diaphragm morphogenesis [GO:0060540],
vasculogenesis involved in coronary vascular morphogenesis [GO:0060979],
cellular response to gonadotropin stimulus [GO:0071371],
cellular response to follicle-stimulating hormone stimulus [GO:0071372],
epithelial cell fate commitment [GO:0072148],
seminiferous tubule development [GO:0072520],
negative regulation of connective tissue replacement [GO:1905204],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II transcription factor binding [GO:0001085],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription coactivator activity [GO:0003713],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
protein kinase binding [GO:0019901],
activating transcription factor binding [GO:0033613],
sequence-specific DNA binding [GO:0043565],
NFAT protein binding [GO:0051525],
co-SMAD binding [GO:0070410],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
chromatin binding [GO:0003682],
metal ion binding [GO:0046872],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nuclear body [GO:0016604],
RNA polymerase II transcription factor complex [GO:0090575],