growth arrest and DNA damage inducible gamma

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23897841 SK-HEP-1, SMMC-7721, Hep 3B Liver Human, mouse NO
26378039 SMMC-7721, HEK 293T, SK-HEP-1 Human, mouse NO
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
activation of MAPKKK activity [GO:0000185],
apoptotic process [GO:0006915],
multicellular organism development [GO:0007275],
cell differentiation [GO:0030154],
positive regulation of apoptotic process [GO:0043065],
positive regulation of JNK cascade [GO:0046330],
regulation of cell cycle [GO:0051726],
positive regulation of p38MAPK cascade [GO:1900745],
activation of MAPKK activity [GO:0000186],
negative regulation of protein kinase activity [GO:0006469],
interferon-gamma biosynthetic process [GO:0042095],
T-helper 1 cell differentiation [GO:0045063],

Molecular Function:
protein binding [GO:0005515],
identical protein binding [GO:0042802],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],