GADD45B
growth arrest and DNA damage inducible beta
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 21353395 | Primary articular chondrocytes | Mouse | NO | |
| 21678067 | C85 | Intestine | Human | NO |
| 29081404 | IMR-90 | Human | NO | |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 27105496 | MEF | Lung | Mouse | NO |
| 32972203 | heartDPI14 vs healthy | Endothelial cell | Mouse | NO |
GO terms:
Biological Process:
activation of MAPKKK activity [GO:0000185],
activation of MAPKK activity [GO:0000186],
negative regulation of protein kinase activity [GO:0006469],
apoptotic process [GO:0006915],
multicellular organism development [GO:0007275],
cell differentiation [GO:0030154],
positive regulation of apoptotic process [GO:0043065],
positive regulation of JNK cascade [GO:0046330],
regulation of cell cycle [GO:0051726],
positive regulation of p38MAPK cascade [GO:1900745],
Molecular Function:
protein binding [GO:0005515],
Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],