growth arrest and DNA damage inducible beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21353395 Primary articular chondrocytes Mouse NO
21678067 C85 Intestine Human NO
29081404 IMR-90 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27105496 MEF Lung Mouse NO
32972203 heartDPI14 vs healthy Endothelial cell Mouse NO

GO terms:

Biological Process:
activation of MAPKKK activity [GO:0000185],
activation of MAPKK activity [GO:0000186],
negative regulation of protein kinase activity [GO:0006469],
apoptotic process [GO:0006915],
multicellular organism development [GO:0007275],
cell differentiation [GO:0030154],
positive regulation of apoptotic process [GO:0043065],
positive regulation of JNK cascade [GO:0046330],
regulation of cell cycle [GO:0051726],
positive regulation of p38MAPK cascade [GO:1900745],

Molecular Function:
protein binding [GO:0005515],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],