GABBR1

gamma-aminobutyric acid type B receptor subunit 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193],
gamma-aminobutyric acid signaling pathway [GO:0007214],
regulation of postsynaptic membrane potential [GO:0060078],
osteoblast differentiation [GO:0001649],
signal transduction [GO:0007165],
negative regulation of adenylate cyclase activity [GO:0007194],
negative regulation of cell proliferation [GO:0008285],
regulation of glutamate secretion [GO:0014048],
positive regulation of glutamate secretion [GO:0014049],
negative regulation of gamma-aminobutyric acid secretion [GO:0014053],
negative regulation of epinephrine secretion [GO:0032811],
negative regulation of dopamine secretion [GO:0033602],
negative regulation of synaptic transmission [GO:0050805],
positive regulation of growth hormone secretion [GO:0060124],

Molecular Function:
transmembrane signaling receptor activity [GO:0004888],
G-protein coupled GABA receptor activity [GO:0004965],
protein binding [GO:0005515],
G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579],
G-protein coupled receptor activity [GO:0004930],
transcription factor binding [GO:0008134],
protein heterodimerization activity [GO:0046982],
extracellular matrix protein binding [GO:1990430],

Cellular Component:
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
dendrite [GO:0030425],
G-protein coupled receptor heterodimeric complex [GO:0038039],
presynaptic membrane [GO:0042734],
postsynaptic membrane [GO:0045211],
GABA-ergic synapse [GO:0098982],
extracellular space [GO:0005615],
endoplasmic reticulum membrane [GO:0005789],
synaptic vesicle [GO:0008021],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
axolemma [GO:0030673],
mitochondrial membrane [GO:0031966],
G-protein coupled receptor dimeric complex [GO:0038037],
cell projection [GO:0042995],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
dendritic shaft [GO:0043198],
intracellular membrane-bounded organelle [GO:0043231],
membrane raft [GO:0045121],
synapse [GO:0045202],
synaptic membrane [GO:0097060],
presynapse [GO:0098793],
glutamatergic synapse [GO:0098978],
integral component of postsynaptic membrane [GO:0099055],
integral component of presynaptic membrane [GO:0099056],
GABA receptor complex [GO:1902710],