frizzled class receptor 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
embryonic axis specification [GO:0000578],
angiogenesis [GO:0001525],
positive regulation of T cell cytokine production [GO:0002726],
G-protein coupled receptor signaling pathway [GO:0007186],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
synapse assembly [GO:0007416],
negative regulation of cell proliferation [GO:0008285],
anterior/posterior axis specification, embryo [GO:0008595],
neuron differentiation [GO:0030182],
post-embryonic camera-type eye development [GO:0031077],
positive regulation of interferon-gamma production [GO:0032729],
T cell differentiation in thymus [GO:0033077],
non-canonical Wnt signaling pathway [GO:0035567],
positive regulation of JUN kinase activity [GO:0043507],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
cell maturation [GO:0048469],
embryonic camera-type eye morphogenesis [GO:0048596],
positive regulation of interleukin-1 beta secretion [GO:0050718],
Spemann organizer formation [GO:0060061],
canonical Wnt signaling pathway [GO:0060070],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
apoptotic process involved in morphogenesis [GO:0060561],
branching involved in labyrinthine layer morphogenesis [GO:0060670],
syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715],
labyrinthine layer blood vessel development [GO:0060716],
chorionic trophoblast cell differentiation [GO:0060718],
cellular response to molecule of bacterial origin [GO:0071219],
regulation of chorionic trophoblast cell proliferation [GO:1901382],
regulation of mitophagy [GO:1903146],
positive regulation of protein targeting to mitochondrion [GO:1903955],
positive regulation of tumor necrosis factor secretion [GO:1904469],
beta-catenin destruction complex disassembly [GO:1904886],
regulation of bicellular tight junction assembly [GO:2000810],
vasculature development [GO:0001944],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
multicellular organism development [GO:0007275],
Wnt signaling pathway [GO:0016055],
cell differentiation [GO:0030154],
embryonic camera-type eye development [GO:0031076],
presynapse assembly [GO:0099054],

Molecular Function:
beta-amyloid binding [GO:0001540],
G-protein coupled receptor activity [GO:0004930],
protein binding [GO:0005515],
lipid binding [GO:0008289],
Wnt-protein binding [GO:0017147],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
Wnt-activated receptor activity [GO:0042813],
macromolecular complex binding [GO:0044877],
transmembrane signaling receptor activity [GO:0004888],

Cellular Component:
Golgi membrane [GO:0000139],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
bicellular tight junction [GO:0005923],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
axon [GO:0030424],
dendrite [GO:0030425],
clathrin-coated endocytic vesicle membrane [GO:0030669],
early endosome membrane [GO:0031901],
perikaryon [GO:0043204],
synapse [GO:0045202],
perinuclear region of cytoplasm [GO:0048471],
early endosome [GO:0005769],
Golgi apparatus [GO:0005794],
membrane [GO:0016020],
cell junction [GO:0030054],
cell projection [GO:0042995],
glutamatergic synapse [GO:0098978],