frizzled class receptor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
30574422 ADSC Human NO

GO terms:

Biological Process:
vasculogenesis [GO:0001570],
G-protein coupled receptor signaling pathway [GO:0007186],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
sensory perception of sound [GO:0007605],
negative regulation of cell-substrate adhesion [GO:0010812],
Wnt signaling pathway [GO:0016055],
cytokine-mediated signaling pathway [GO:0019221],
neuron differentiation [GO:0030182],
regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947],
locomotion involved in locomotory behavior [GO:0031987],
substrate adhesion-dependent cell spreading [GO:0034446],
extracellular matrix-cell signaling [GO:0035426],
non-canonical Wnt signaling pathway [GO:0035567],
progesterone secretion [GO:0042701],
positive regulation of JUN kinase activity [GO:0043507],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
canonical Wnt signaling pathway [GO:0060070],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
membrane organization [GO:0061024],
retina vasculature morphogenesis in camera-type eye [GO:0061299],
cerebellum vasculature morphogenesis [GO:0061301],
retinal blood vessel morphogenesis [GO:0061304],
cellular response to retinoic acid [GO:0071300],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
cellular response to leukemia inhibitory factor [GO:1990830],
luteinization [GO:0001553],
blood vessel development [GO:0001568],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
multicellular organism development [GO:0007275],

Molecular Function:
beta-amyloid binding [GO:0001540],
cytokine receptor activity [GO:0004896],
G-protein coupled receptor activity [GO:0004930],
protein binding [GO:0005515],
Wnt-protein binding [GO:0017147],
cytokine binding [GO:0019955],
PDZ domain binding [GO:0030165],
ubiquitin protein ligase binding [GO:0031625],
signaling receptor activity [GO:0038023],
protein homodimerization activity [GO:0042803],
Wnt-activated receptor activity [GO:0042813],
macromolecular complex binding [GO:0044877],
protein heterodimerization activity [GO:0046982],
transmembrane signaling receptor activity [GO:0004888],

Cellular Component:
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell-cell junction [GO:0005911],
cell surface [GO:0009986],
dendrite [GO:0030425],
clathrin-coated vesicle membrane [GO:0030665],
clathrin-coated endocytic vesicle membrane [GO:0030669],
glutamatergic synapse [GO:0098978],
membrane [GO:0016020],
synapse [GO:0045202],