frizzled class receptor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
membranous septum morphogenesis [GO:0003149],
muscular septum morphogenesis [GO:0003150],
outflow tract morphogenesis [GO:0003151],
G-protein coupled receptor signaling pathway [GO:0007186],
cell-cell signaling [GO:0007267],
positive regulation of neuron projection development [GO:0010976],
neuron differentiation [GO:0030182],
negative regulation of BMP signaling pathway [GO:0030514],
epithelial cell differentiation [GO:0030855],
autocrine signaling [GO:0035425],
non-canonical Wnt signaling pathway [GO:0035567],
astrocyte-dopaminergic neuron signaling [GO:0036520],
response to drug [GO:0042493],
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338],
canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
hard palate development [GO:0060022],
canonical Wnt signaling pathway [GO:0060070],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
planar cell polarity pathway involved in neural tube closure [GO:0090179],
presynapse assembly [GO:0099054],
negative regulation of oxidative stress-induced neuron death [GO:1903204],
beta-catenin destruction complex disassembly [GO:1904886],
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
multicellular organism development [GO:0007275],
Wnt signaling pathway [GO:0016055],
ventricular septum morphogenesis [GO:0060412],

Molecular Function:
G-protein coupled receptor activity [GO:0004930],
receptor binding [GO:0005102],
frizzled binding [GO:0005109],
protein binding [GO:0005515],
Wnt-protein binding [GO:0017147],
PDZ domain binding [GO:0030165],
Wnt-activated receptor activity [GO:0042813],
transmembrane signaling receptor activity [GO:0004888],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],

Cellular Component:
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
Wnt signalosome [GO:1990909],
membrane [GO:0016020],
neuron projection [GO:0043005],