FYN

FYN proto-oncogene, Src family tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
32781064 Heart Mouse NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
response to singlet oxygen [GO:0000304],
neuron migration [GO:0001764],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
adaptive immune response [GO:0002250],
heart process [GO:0003015],
protein phosphorylation [GO:0006468],
calcium ion transport [GO:0006816],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
axon guidance [GO:0007411],
blood coagulation [GO:0007596],
learning [GO:0007612],
feeding behavior [GO:0007631],
regulation of cell shape [GO:0008360],
negative regulation of gene expression [GO:0010629],
negative regulation of hydrogen peroxide biosynthetic process [GO:0010730],
positive regulation of neuron projection development [GO:0010976],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
peptidyl-tyrosine phosphorylation [GO:0018108],
cytokine-mediated signaling pathway [GO:0019221],
cell differentiation [GO:0030154],
platelet activation [GO:0030168],
forebrain development [GO:0030900],
T cell costimulation [GO:0031295],
negative regulation of protein ubiquitination [GO:0031397],
intracellular signal transduction [GO:0035556],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
peptidyl-tyrosine autophosphorylation [GO:0038083],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
regulation of cell proliferation [GO:0042127],
negative regulation of protein catabolic process [GO:0042177],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
response to hydrogen peroxide [GO:0042542],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
negative regulation of neuron apoptotic process [GO:0043524],
innate immune response [GO:0045087],
response to ethanol [GO:0045471],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
ephrin receptor signaling pathway [GO:0048013],
dendrite morphogenesis [GO:0048813],
regulation of defense response to virus by virus [GO:0050690],
regulation of peptidyl-tyrosine phosphorylation [GO:0050730],
activated T cell proliferation [GO:0050798],
modulation of synaptic transmission [GO:0050804],
T cell receptor signaling pathway [GO:0050852],
leukocyte migration [GO:0050900],
detection of mechanical stimulus involved in sensory perception of pain [GO:0050966],
positive regulation of protein kinase B signaling [GO:0051897],
cellular response to peptide hormone stimulus [GO:0071375],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of protein targeting to membrane [GO:0090314],
dendritic spine maintenance [GO:0097062],
positive regulation of protein localization to nucleus [GO:1900182],
regulation of glutamate receptor signaling pathway [GO:1900449],
positive regulation of neuron death [GO:1901216],
negative regulation of dendritic spine maintenance [GO:1902951],
negative regulation of oxidative stress-induced cell death [GO:1903202],
positive regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903997],
response to beta-amyloid [GO:1904645],
cellular response to beta-amyloid [GO:1904646],
cellular response to L-glutamate [GO:1905232],
cellular response to glycine [GO:1905430],
positive regulation of protein localization to membrane [GO:1905477],
positive regulation of cysteine-type endopeptidase activity [GO:2001056],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
immune system process [GO:0002376],
cell surface receptor signaling pathway [GO:0007166],
multicellular organism development [GO:0007275],
phosphorylation [GO:0016310],
myelination [GO:0042552],
protein autophosphorylation [GO:0046777],

Molecular Function:
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
receptor binding [GO:0005102],
protein binding [GO:0005515],
ATP binding [GO:0005524],
enzyme binding [GO:0019899],
type 5 metabotropic glutamate receptor binding [GO:0031802],
T cell receptor binding [GO:0042608],
CD4 receptor binding [GO:0042609],
CD8 receptor binding [GO:0042610],
identical protein binding [GO:0042802],
alpha-tubulin binding [GO:0043014],
phosphatidylinositol 3-kinase binding [GO:0043548],
ion channel binding [GO:0044325],
metal ion binding [GO:0046872],
ephrin receptor binding [GO:0046875],
tau protein binding [GO:0048156],
tau-protein kinase activity [GO:0050321],
peptide hormone receptor binding [GO:0051428],
growth factor receptor binding [GO:0070851],
disordered domain specific binding [GO:0097718],
nucleotide binding [GO:0000166],
G-protein coupled receptor binding [GO:0001664],
protein kinase activity [GO:0004672],
tubulin binding [GO:0015631],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleus [GO:0005634],
mitochondrion [GO:0005739],
endosome [GO:0005768],
cytosol [GO:0005829],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
postsynaptic density [GO:0014069],
dendrite [GO:0030425],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
cell body [GO:0044297],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
perinuclear endoplasmic reticulum [GO:0097038],
glial cell projection [GO:0097386],
glutamatergic synapse [GO:0098978],
cytoplasm [GO:0005737],
membrane [GO:0016020],
intracellular membrane-bounded organelle [GO:0043231],
cell periphery [GO:0071944],