alsin Rho guanine nucleotide exchange factor ALS2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
behavioral fear response [GO:0001662],
in utero embryonic development [GO:0001701],
receptor recycling [GO:0001881],
response to oxidative stress [GO:0006979],
endosome organization [GO:0007032],
lysosomal transport [GO:0007041],
axonogenesis [GO:0007409],
neuromuscular junction development [GO:0007528],
locomotory behavior [GO:0007626],
protein localization [GO:0008104],
cell death [GO:0008219],
endosomal transport [GO:0016197],
Rac protein signal transduction [GO:0016601],
positive regulation of Rac protein signal transduction [GO:0035022],
synaptic transmission, glutamatergic [GO:0035249],
positive regulation of GTPase activity [GO:0043547],
positive regulation of protein kinase activity [GO:0045860],
neuron projection morphogenesis [GO:0048812],
regulation of endosome size [GO:0051036],
protein homooligomerization [GO:0051260],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
vesicle organization [GO:0016050],
regulation of Rho protein signal transduction [GO:0035023],
regulation of GTPase activity [GO:0043087],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
Rab guanyl-nucleotide exchange factor activity [GO:0017112],
Rab GTPase binding [GO:0017137],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein serine/threonine kinase activator activity [GO:0043539],
Rac GTPase binding [GO:0048365],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],

Cellular Component:
ruffle [GO:0001726],
nucleus [GO:0005634],
early endosome [GO:0005769],
centrosome [GO:0005813],
cytosol [GO:0005829],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
lamellipodium [GO:0030027],
dendrite [GO:0030425],
growth cone [GO:0030426],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
cytoplasm [GO:0005737],
axon [GO:0030424],
neuron projection [GO:0043005],
intracellular membrane-bounded organelle [GO:0043231],