FOXO3

forkhead box O3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20656682 2BS Human NO
23746120 2BS Human NO
25753771 Primary multipotent precursors derived from skin Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31442231 Muscle Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
15741276 HDF Human NO
21707762 BJ1-hTERT Human NO
22546858 Lung Human, mouse NO
25000517 HUC-F2 Human NO
25165029 Hs27 Human NO
25344604 MEF Mouse NO
25655933 Primary endothelial cells derived from blood vessels Human NO
27470586 HCT 116, MCF7 Human NO
28989024 IMR-90, HCT 116, 293T Human NO
32109515 Primary lung endothelial cells, HUVEC Human, Mouse NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
ovulation from ovarian follicle [GO:0001542],
initiation of primordial ovarian follicle growth [GO:0001544],
antral ovarian follicle growth [GO:0001547],
oocyte maturation [GO:0001556],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription from mitochondrial promoter [GO:0006390],
regulation of translation [GO:0006417],
aging [GO:0007568],
insulin receptor signaling pathway [GO:0008286],
positive regulation of autophagy [GO:0010508],
positive regulation of muscle atrophy [GO:0014737],
cytokine-mediated signaling pathway [GO:0019221],
DNA damage response, signal transduction by p53 class mediator [GO:0030330],
negative regulation of cell migration [GO:0030336],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
cellular response to oxidative stress [GO:0034599],
cellular response to glucose starvation [GO:0042149],
glucose homeostasis [GO:0042593],
response to starvation [GO:0042594],
positive regulation of apoptotic process [GO:0043065],
positive regulation of neuron apoptotic process [GO:0043525],
positive regulation of erythrocyte differentiation [GO:0045648],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
brain morphogenesis [GO:0048854],
response to fatty acid [GO:0070542],
cellular response to glucose stimulus [GO:0071333],
cellular response to corticosterone stimulus [GO:0071386],
cellular response to hypoxia [GO:0071456],
response to dexamethasone [GO:0071548],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
neuronal stem cell population maintenance [GO:0097150],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
positive regulation of reactive oxygen species biosynthetic process [GO:1903428],
cellular response to beta-amyloid [GO:1904646],
cellular response to nerve growth factor stimulus [GO:1990090],
response to water-immersion restraint stress [GO:1990785],
regulation of neural precursor cell proliferation [GO:2000177],
positive regulation of endothelial cell apoptotic process [GO:2000353],
regulation of transcription, DNA-templated [GO:0006355],
apoptotic process [GO:0006915],
regulation of reactive oxygen species metabolic process [GO:2000377],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcription cofactor binding [GO:0001221],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
transcription factor binding [GO:0008134],
protein kinase binding [GO:0019901],
chromatin DNA binding [GO:0031490],
mitochondrial RNA polymerase binding promoter specificity activity [GO:0034246],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
mitochondrial matrix [GO:0005759],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
membrane [GO:0016020],