FOXA2

forkhead box A2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432],
cell fate specification [GO:0001708],
chromatin organization [GO:0006325],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
adult locomotory behavior [GO:0008344],
anatomical structure morphogenesis [GO:0009653],
negative regulation of epithelial to mesenchymal transition [GO:0010719],
cell differentiation [GO:0030154],
regulation of blood coagulation [GO:0030193],
endocrine pancreas development [GO:0031018],
negative regulation of glucokinase activity [GO:0033132],
positive regulation of embryonic development [GO:0040019],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178],
response to interleukin-6 [GO:0070741],
dopaminergic neuron differentiation [GO:0071542],
primitive streak formation [GO:0090009],
positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049],
positive regulation of gastrulation [GO:2000543],
negative regulation of detection of glucose [GO:2000971],
in utero embryonic development [GO:0001701],
ectoderm formation [GO:0001705],
regulation of transcription, DNA-templated [GO:0006355],
Notch signaling pathway [GO:0007219],
multicellular organism development [GO:0007275],
pattern specification process [GO:0007389],
anterior/posterior pattern specification [GO:0009952],
dorsal/ventral pattern formation [GO:0009953],
regulation of gene expression [GO:0010468],
regulation of lipid metabolic process [GO:0019216],
regulation of steroid metabolic process [GO:0019218],
cell differentiation in hindbrain [GO:0021533],
dorsal/ventral neural tube patterning [GO:0021904],
signal transduction involved in regulation of gene expression [GO:0023019],
lung development [GO:0030324],
somite rostral/caudal axis specification [GO:0032525],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of smoothened signaling pathway [GO:0045880],
positive regulation of transcription from RNA polymerase III promoter [GO:0045945],
mesendoderm development [GO:0048382],
cell development [GO:0048468],
anatomical structure formation involved in morphogenesis [GO:0048646],
neuron fate specification [GO:0048665],
epithelial tube branching involved in lung morphogenesis [GO:0060441],
lung epithelial cell differentiation [GO:0060487],
connective tissue development [GO:0061448],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription factor binding [GO:0008134],
protein domain specific binding [GO:0019904],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
chromatin binding [GO:0003682],
double-stranded DNA binding [GO:0003690],
protein binding [GO:0005515],
obsolete general RNA polymerase II transcription factor activity [GO:0016251],
kinase binding [GO:0019900],
sequence-specific DNA binding [GO:0043565],
SMAD binding [GO:0046332],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cell junction [GO:0030054],
transcription factor complex [GO:0005667],