ALOX5AP
arachidonate 5-lipoxygenase activating protein
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 27323328 | Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni | Human | YES | |
| 29548335 | Saos-2, Li-Fraumeni | Human | YES | |
| 30988157 | IMR-90 | Human | YES | |
| 31687975 | IMR-90 | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
GO terms:
Biological Process:
leukotriene metabolic process [GO:0006691],
leukotriene biosynthetic process [GO:0019370],
lipoxygenase pathway [GO:0019372],
positive regulation of catalytic activity [GO:0043085],
protein homotrimerization [GO:0070207],
cellular response to calcium ion [GO:0071277],
cellular oxidant detoxification [GO:0098869],
lipoxin biosynthetic process [GO:2001301],
leukotriene production involved in inflammatory response [GO:0002540],
positive regulation of acute inflammatory response [GO:0002675],
Molecular Function:
glutathione transferase activity [GO:0004364],
leukotriene-C4 synthase activity [GO:0004464],
glutathione peroxidase activity [GO:0004602],
protein binding [GO:0005515],
enzyme activator activity [GO:0008047],
protein N-terminus binding [GO:0047485],
arachidonic acid binding [GO:0050544],
arachidonate 5-lipoxygenase activity [GO:0004051],
enzyme binding [GO:0019899],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
Cellular Component:
nuclear envelope [GO:0005635],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
nuclear membrane [GO:0031965],
nucleus [GO:0005634],
cytosol [GO:0005829],