FOLH1

folate hydrolase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
folic acid-containing compound metabolic process [GO:0006760],
cellular amino acid biosynthetic process [GO:0008652],
C-terminal protein deglutamylation [GO:0035609],
metabolic process [GO:0008152],
positive regulation of apoptotic process [GO:0043065],

Molecular Function:
carboxypeptidase activity [GO:0004180],
metallocarboxypeptidase activity [GO:0004181],
peptidase activity [GO:0008233],
dipeptidase activity [GO:0016805],
metal ion binding [GO:0046872],
Ac-Asp-Glu binding [GO:1904492],
tetrahydrofolyl-poly(glutamate) polymer binding [GO:1904493],
catalytic activity [GO:0003824],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],

Cellular Component:
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
membrane [GO:0016020],
extracellular exosome [GO:0070062],
integral component of membrane [GO:0016021],