arachidonate 5-lipoxygenase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15616590 IMR-90, LF1, WI-38, MEF Human, mouse NO
31687975 IMR-90 Human YES

GO terms:

Biological Process:
negative regulation of endothelial cell proliferation [GO:0001937],
leukocyte chemotaxis involved in inflammatory response [GO:0002232],
leukocyte migration involved in inflammatory response [GO:0002523],
leukotriene production involved in inflammatory response [GO:0002540],
leukotriene metabolic process [GO:0006691],
humoral immune response [GO:0006959],
negative regulation of angiogenesis [GO:0016525],
cytokine-mediated signaling pathway [GO:0019221],
arachidonic acid metabolic process [GO:0019369],
leukotriene biosynthetic process [GO:0019370],
lipoxygenase pathway [GO:0019372],
positive regulation of bone mineralization [GO:0030501],
lipid oxidation [GO:0034440],
interleukin-18-mediated signaling pathway [GO:0035655],
dendritic cell migration [GO:0036336],
glucose homeostasis [GO:0042593],
long-chain fatty acid biosynthetic process [GO:0042759],
neutrophil degranulation [GO:0043312],
linoleic acid metabolic process [GO:0043651],
regulation of fat cell differentiation [GO:0045598],
regulation of inflammatory response [GO:0050727],
negative regulation of inflammatory response [GO:0050728],
regulation of insulin secretion [GO:0050796],
hepoxilin biosynthetic process [GO:0051122],
negative regulation of vascular wound healing [GO:0061044],
negative regulation of wound healing [GO:0061045],
regulation of cytokine production involved in inflammatory response [GO:1900015],
regulation of cellular response to oxidative stress [GO:1900407],
leukotriene A4 biosynthetic process [GO:1901753],
regulation of reactive oxygen species biosynthetic process [GO:1903426],
negative regulation of response to endoplasmic reticulum stress [GO:1903573],
negative regulation of sprouting angiogenesis [GO:1903671],
positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999],
lipoxin biosynthetic process [GO:2001301],
acute inflammatory response [GO:0002526],
inflammatory response [GO:0006954],
sensory perception of pain [GO:0019233],
positive regulation of vasoconstriction [GO:0045907],
oxidation-reduction process [GO:0055114],
positive regulation of cytochrome-c oxidase activity [GO:1904960],

Molecular Function:
arachidonate 5-lipoxygenase activity [GO:0004051],
iron ion binding [GO:0005506],
protein binding [GO:0005515],
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702],
oxidoreductase activity [GO:0016491],
metal ion binding [GO:0046872],
dioxygenase activity [GO:0051213],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nuclear envelope [GO:0005635],
nuclear envelope lumen [GO:0005641],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
nuclear matrix [GO:0016363],
nuclear membrane [GO:0031965],
secretory granule lumen [GO:0034774],
perinuclear region of cytoplasm [GO:0048471],
ficolin-1-rich granule lumen [GO:1904813],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
membrane [GO:0016020],
dendrite [GO:0030425],
sarcolemma [GO:0042383],