FMR1

FMRP translational regulator 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
regulation of alternative mRNA splicing, via spliceosome [GO:0000381],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of receptor internalization [GO:0002092],
mRNA processing [GO:0006397],
cellular response to DNA damage stimulus [GO:0006974],
glutamate receptor signaling pathway [GO:0007215],
RNA splicing [GO:0008380],
viral process [GO:0016032],
negative regulation of translation [GO:0017148],
gene silencing by RNA [GO:0031047],
positive regulation of histone phosphorylation [GO:0033129],
cellular response to UV [GO:0034644],
regulation of mRNA stability [GO:0043488],
modulation by host of viral RNA genome replication [GO:0044830],
positive regulation of translation [GO:0045727],
negative regulation of translational initiation [GO:0045947],
regulation of neurotransmitter secretion [GO:0046928],
mRNA transport [GO:0051028],
regulation of filopodium assembly [GO:0051489],
positive regulation of filopodium assembly [GO:0051491],
regulation of gene silencing by miRNA [GO:0060964],
regulation of dendritic spine development [GO:0060998],
positive regulation of dendritic spine development [GO:0060999],
cellular response to hydroxyurea [GO:0072711],
cellular response to virus [GO:0098586],
regulation of neuronal action potential [GO:0098908],
negative regulation of long term synaptic depression [GO:1900453],
positive regulation of intracellular transport of viral material [GO:1901254],
negative regulation of voltage-gated calcium channel activity [GO:1901386],
positive regulation of proteasomal protein catabolic process [GO:1901800],
negative regulation of mRNA catabolic process [GO:1902373],
positive regulation of mRNA binding [GO:1902416],
negative regulation of synaptic vesicle exocytosis [GO:2000301],
positive regulation of gene silencing by miRNA [GO:2000637],
negative regulation of cytoplasmic translation [GO:2000766],
positive regulation of response to DNA damage stimulus [GO:2001022],
negative regulation of receptor internalization [GO:0002091],
regulation of translation [GO:0006417],
nervous system development [GO:0007399],
central nervous system development [GO:0007417],
anterograde axonal transport [GO:0008089],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of protein processing [GO:0010955],
negative regulation of neuron apoptotic process [GO:0043524],
negative regulation of neuron differentiation [GO:0045665],
dendritic spine development [GO:0060996],
regulation of translation at presynapse, modulating synaptic transmission [GO:0099577],
regulation of translation at postsynapse, modulating synaptic transmission [GO:0099578],
regulation of modification of synaptic structure [GO:1905244],

Molecular Function:
G-quadruplex RNA binding [GO:0002151],
chromatin binding [GO:0003682],
RNA binding [GO:0003723],
mRNA binding [GO:0003729],
mRNA 3'-UTR binding [GO:0003730],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
poly(U) RNA binding [GO:0008266],
translation repressor activity [GO:0030371],
translation initiation factor binding [GO:0031369],
RNA strand annealing activity [GO:0033592],
poly(G) binding [GO:0034046],
methylated histone binding [GO:0035064],
siRNA binding [GO:0035197],
miRNA binding [GO:0035198],
RNA stem-loop binding [GO:0035613],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
ribosome binding [GO:0043022],
ion channel binding [GO:0044325],
translation regulator activity [GO:0045182],
protein heterodimerization activity [GO:0046982],
mRNA 5'-UTR binding [GO:0048027],
dynein complex binding [GO:0070840],
sequence-specific mRNA binding [GO:1990825],
RNA 7-methylguanosine cap binding [GO:0000340],
nucleic acid binding [GO:0003676],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
protein domain specific binding [GO:0019904],

Cellular Component:
chromosome, centromeric region [GO:0000775],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
chromosome [GO:0005694],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
polysome [GO:0005844],
mRNA cap binding complex [GO:0005845],
chromocenter [GO:0010369],
cytoplasmic stress granule [GO:0010494],
postsynaptic density [GO:0014069],
Cajal body [GO:0015030],
membrane [GO:0016020],
viral replication complex [GO:0019034],
extrinsic component of plasma membrane [GO:0019897],
axon [GO:0030424],
dendrite [GO:0030425],
growth cone [GO:0030426],
filopodium tip [GO:0032433],
SMN complex [GO:0032797],
ribonucleoprotein granule [GO:0035770],
cytoplasmic ribonucleoprotein granule [GO:0036464],
presynaptic membrane [GO:0042734],
polysomal ribosome [GO:0042788],
cell projection [GO:0042995],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
perikaryon [GO:0043204],
axon terminus [GO:0043679],
dendritic spine neck [GO:0044326],
synapse [GO:0045202],
postsynaptic membrane [GO:0045211],
perinuclear region of cytoplasm [GO:0048471],
neuronal ribonucleoprotein granule [GO:0071598],
glial cell projection [GO:0097386],
presynapse [GO:0098793],
postsynapse [GO:0098794],
dendritic filopodium [GO:1902737],
messenger ribonucleoprotein complex [GO:1990124],
growth cone filopodium [GO:1990812],
ribonucleoprotein complex [GO:1990904],
smooth endoplasmic reticulum [GO:0005790],
rough endoplasmic reticulum [GO:0005791],
microtubule [GO:0005874],
plasma membrane [GO:0005886],
cell junction [GO:0030054],
terminal bouton [GO:0043195],
cell body [GO:0044297],
dendritic spine head [GO:0044327],
spine apparatus [GO:0097444],
glutamatergic synapse [GO:0098978],
presynaptic cytosol [GO:0099523],
postsynaptic cytosol [GO:0099524],
proximal dendrite [GO:1990635],