FLT4

fms related receptor tyrosine kinase 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of endothelial cell proliferation [GO:0001938],
vasculature development [GO:0001944],
lymph vessel development [GO:0001945],
lymphangiogenesis [GO:0001946],
sprouting angiogenesis [GO:0002040],
hematopoietic progenitor cell differentiation [GO:0002244],
respiratory system process [GO:0003016],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
multicellular organism development [GO:0007275],
positive regulation of cell proliferation [GO:0008284],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of endothelial cell migration [GO:0010595],
peptidyl-tyrosine phosphorylation [GO:0018108],
positive regulation of kinase activity [GO:0033674],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
vascular endothelial growth factor signaling pathway [GO:0038084],
negative regulation of apoptotic process [GO:0043066],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of JNK cascade [GO:0046330],
protein autophosphorylation [GO:0046777],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
lung alveolus development [GO:0048286],
blood vessel morphogenesis [GO:0048514],
regulation of blood vessel remodeling [GO:0060312],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of protein kinase C signaling [GO:0090037],
angiogenesis [GO:0001525],
protein phosphorylation [GO:0006468],
respiratory gaseous exchange [GO:0007585],
phosphorylation [GO:0016310],
positive regulation of cell growth [GO:0030307],

Molecular Function:
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
vascular endothelial growth factor-activated receptor activity [GO:0005021],
protein binding [GO:0005515],
ATP binding [GO:0005524],
growth factor binding [GO:0019838],
protein phosphatase binding [GO:0019903],
VEGF-C-activated receptor activity [GO:0036328],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein tyrosine kinase activity [GO:0004713],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
extracellular region [GO:0005576],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
receptor complex [GO:0043235],
nucleus [GO:0005634],
membrane [GO:0016020],
integral component of membrane [GO:0016021],