ALOX15B

arachidonate 15-lipoxygenase type B

Link to human ortholog


Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15750631 NHP2, NHP4, NHP6 , NHP7 primary cell lines, PC3 Human NO
20514017 Prostate gland Mouse NO
24732589 Prostate gland Mouse NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
30988157 IMR-90 Human YES
31687975 IMR-90 Human YES

GO terms:

Biological Process:
lipid metabolic process [GO:0006629],
phospholipid metabolic process [GO:0006644],
apoptotic process [GO:0006915],
negative regulation of cell proliferation [GO:0008285],
positive regulation of macrophage derived foam cell differentiation [GO:0010744],
arachidonic acid metabolic process [GO:0019369],
lipoxygenase pathway [GO:0019372],
negative regulation of cell migration [GO:0030336],
prostate gland development [GO:0030850],
regulation of epithelial cell differentiation [GO:0030856],
lipid oxidation [GO:0034440],
positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360],
linoleic acid metabolic process [GO:0043651],
positive regulation of keratinocyte differentiation [GO:0045618],
negative regulation of cell cycle [GO:0045786],
negative regulation of growth [GO:0045926],
hepoxilin biosynthetic process [GO:0051122],
endocannabinoid signaling pathway [GO:0071926],
positive regulation of chemokine secretion [GO:0090197],
cannabinoid biosynthetic process [GO:1901696],
lipoxin A4 biosynthetic process [GO:2001303],

Molecular Function:
iron ion binding [GO:0005506],
calcium ion binding [GO:0005509],
lipid binding [GO:0008289],
linoleate 13S-lipoxygenase activity [GO:0016165],
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702],
arachidonate 8(S)-lipoxygenase activity [GO:0036403],
arachidonate 15-lipoxygenase activity [GO:0050473],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
focal adhesion [GO:0005925],
membrane [GO:0016020],
extrinsic component of membrane [GO:0019898],
extracellular exosome [GO:0070062],