FLOT1

flotillin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
membrane raft assembly [GO:0001765],
positive regulation of cytokine production [GO:0001819],
positive regulation of protein phosphorylation [GO:0001934],
regulation of receptor internalization [GO:0002090],
axonogenesis [GO:0007409],
extracellular matrix disassembly [GO:0022617],
positive regulation of protein binding [GO:0032092],
positive regulation of synaptic transmission, dopaminergic [GO:0032226],
positive regulation of interferon-beta production [GO:0032728],
dsRNA transport [GO:0033227],
positive regulation of heterotypic cell-cell adhesion [GO:0034116],
positive regulation of toll-like receptor 3 signaling pathway [GO:0034141],
regulation of toll-like receptor 4 signaling pathway [GO:0034143],
response to endoplasmic reticulum stress [GO:0034976],
regulation of Rho protein signal transduction [GO:0035023],
plasma membrane raft assembly [GO:0044854],
positive regulation of endocytosis [GO:0045807],
positive regulation of skeletal muscle tissue development [GO:0048643],
protein stabilization [GO:0050821],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
regulation of neurotransmitter uptake [GO:0051580],
positive regulation of cell adhesion molecule production [GO:0060355],
protein kinase C signaling [GO:0070528],
cellular response to exogenous dsRNA [GO:0071360],
protein localization to plasma membrane [GO:0072659],
positive regulation of myoblast fusion [GO:1901741],
positive regulation of cell junction assembly [GO:1901890],
protein localization to membrane raft [GO:1903044],
positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049],
endocytosis [GO:0006897],
axon guidance [GO:0007411],

Molecular Function:
protease binding [GO:0002020],
protein binding [GO:0005515],
ionotropic glutamate receptor binding [GO:0035255],

Cellular Component:
uropod [GO:0001931],
lysosomal membrane [GO:0005765],
endosome [GO:0005768],
early endosome [GO:0005769],
microtubule organizing center [GO:0005815],
plasma membrane [GO:0005886],
caveola [GO:0005901],
cell-cell junction [GO:0005911],
adherens junction [GO:0005912],
focal adhesion [GO:0005925],
COP9 signalosome [GO:0008180],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
flotillin complex [GO:0016600],
lamellipodium [GO:0030027],
cortical actin cytoskeleton [GO:0030864],
cytoplasmic vesicle [GO:0031410],
centriolar satellite [GO:0034451],
sarcolemma [GO:0042383],
melanosome [GO:0042470],
cell-cell contact zone [GO:0044291],
membrane raft [GO:0045121],
presynaptic active zone [GO:0048786],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
plasma membrane raft [GO:0044853],
synapse [GO:0045202],
presynapse [GO:0098793],