ALOX15

arachidonate 15-lipoxygenase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31687975 IMR-90 Human YES

GO terms:

Biological Process:
ossification [GO:0001503],
negative regulation of adaptive immune response [GO:0002820],
lipid metabolic process [GO:0006629],
phosphatidylethanolamine biosynthetic process [GO:0006646],
leukotriene metabolic process [GO:0006691],
inflammatory response [GO:0006954],
positive regulation of cell-substrate adhesion [GO:0010811],
cytokine-mediated signaling pathway [GO:0019221],
arachidonic acid metabolic process [GO:0019369],
lipoxygenase pathway [GO:0019372],
fatty acid oxidation [GO:0019395],
bone mineralization [GO:0030282],
positive regulation of actin filament polymerization [GO:0030838],
positive regulation of heterotypic cell-cell adhesion [GO:0034116],
lipid oxidation [GO:0034440],
response to endoplasmic reticulum stress [GO:0034976],
regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358],
cellular response to interleukin-13 [GO:0035963],
wound healing [GO:0042060],
long-chain fatty acid biosynthetic process [GO:0042759],
apoptotic cell clearance [GO:0043277],
linoleic acid metabolic process [GO:0043651],
regulation of inflammatory response [GO:0050727],
hepoxilin biosynthetic process [GO:0051122],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to calcium ion [GO:0071277],
regulation of engulfment of apoptotic cell [GO:1901074],
lipoxin A4 biosynthetic process [GO:2001303],
fatty acid metabolic process [GO:0006631],
oxidation-reduction process [GO:0055114],

Molecular Function:
arachidonate 12-lipoxygenase activity [GO:0004052],
iron ion binding [GO:0005506],
protein binding [GO:0005515],
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546],
linoleate 13S-lipoxygenase activity [GO:0016165],
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702],
hepoxilin-epoxide hydrolase activity [GO:0047977],
arachidonate 15-lipoxygenase activity [GO:0050473],
hepoxilin A3 synthase activity [GO:0051120],
lipid binding [GO:0008289],
oxidoreductase activity [GO:0016491],
metal ion binding [GO:0046872],
dioxygenase activity [GO:0051213],

Cellular Component:
lipid particle [GO:0005811],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
cytoplasm [GO:0005737],