arachidonate 12-lipoxygenase, 12S type

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31687975 IMR-90 Human YES

GO terms:

Biological Process:
lipid metabolic process [GO:0006629],
aging [GO:0007568],
positive regulation of gene expression [GO:0010628],
negative regulation of muscle cell apoptotic process [GO:0010656],
arachidonic acid metabolic process [GO:0019369],
lipoxygenase pathway [GO:0019372],
fatty acid oxidation [GO:0019395],
unsaturated fatty acid metabolic process [GO:0033559],
lipid oxidation [GO:0034440],
superoxide anion generation [GO:0042554],
long-chain fatty acid biosynthetic process [GO:0042759],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
linoleic acid metabolic process [GO:0043651],
positive regulation of smooth muscle cell proliferation [GO:0048661],
hepoxilin metabolic process [GO:0051121],
hepoxilin biosynthetic process [GO:0051122],
positive regulation of mitochondrial depolarization [GO:0051901],
establishment of skin barrier [GO:0061436],
cellular response to lipid [GO:0071396],
negative regulation of platelet aggregation [GO:0090331],
leukotriene A4 metabolic process [GO:1901751],
lipoxin biosynthetic process [GO:2001301],
lipoxin A4 biosynthetic process [GO:2001303],
lipoxin B4 biosynthetic process [GO:2001306],
fatty acid metabolic process [GO:0006631],
positive regulation of cell death [GO:0010942],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],

Molecular Function:
arachidonate 12-lipoxygenase activity [GO:0004052],
iron ion binding [GO:0005506],
protein binding [GO:0005515],
linoleate 13S-lipoxygenase activity [GO:0016165],
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702],
hepoxilin-epoxide hydrolase activity [GO:0047977],
arachidonate 15-lipoxygenase activity [GO:0050473],
oxidoreductase activity [GO:0016491],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],
dioxygenase activity [GO:0051213],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
sarcolemma [GO:0042383],
extracellular exosome [GO:0070062],